From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease.

Author: Alves PereiraEron Lincoln, Fernandes-PedrosaMatheus de Freitas, GomesDaniele Cavalcante, MedeirosThayse Silva, da SilvaJoão Felipe Oliveira, da Silva-JúniorArnóbio Antônio, de Freitas OliveiraJohny W, de Sousa da SilvaMarcelo

Paper Details 
Original Abstract of the Article :
Chagas disease is a neglected tropical disease caused by the protozoan <i>Trypanosoma cruzi</i>. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both drugs present side effects and efficacy problems, especially in the chronic phase of this disease. Therefore, new mole...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530915/

データ提供:米国国立医学図書館(NLM)

Chagas Disease: A Quest for New Oasis in the Desert of Neglect

Chagas disease, a neglected tropical disease caused by the parasite *Trypanosoma cruzi*, is like a hidden oasis in the desert of global health. This disease affects millions of people worldwide, primarily in Latin America, but research and treatment options have lagged behind other more prevalent diseases. This study explores the potential of nanotechnology in developing more effective treatments for Chagas disease. It's like bringing a caravan of camels laden with advanced technology to this neglected corner of the world.

The researchers review the limitations of current medications, benznidazole and nifurtimox, highlighting their side effects and limited efficacy, especially in the chronic phase of the disease. They explore the use of nanotechnology to improve drug delivery, enhance bioavailability, and reduce toxicity. They highlight the potential of nanocarriers to modulate the immune system, boosting the body's defense against the parasite.

Nanotechnology: A Beacon of Hope in the Desert of Chagas

This research offers hope for the millions affected by Chagas disease. Nanotechnology holds the potential to revolutionize treatment by enhancing drug delivery, targeting the parasite more effectively, and minimizing side effects.

Navigating the Desert of Neglect: Addressing Global Health Disparities

Chagas disease is a stark reminder of the global health disparities that exist. Investing in research and development for neglected diseases is crucial to improving health outcomes for all.

Dr. Camel's Conclusion

Nanotechnology offers a promising oasis in the desert of Chagas disease. Its potential to enhance drug delivery and improve treatment outcomes provides a glimmer of hope for millions affected by this neglected tropical disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-03
Further Info :

Pubmed ID

37762080

DOI: Digital Object Identifier

PMC10530915

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.