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Uncovering a dose-response relationship between positive fecal immunochemical test (FIT) and all-cause, cardiovascular and cancer-related mortality.

Author: ChenChien Hua, ChiouHung Yi, ChuTa-Wei David, LeeJune Han, TsaiMin Kuang, WenChi Pang, WenChristopher

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A positive fecal immunochemical test (FIT) was associated with increased mortality and shortened life expectancy by 4 years, even with colorectal cancer (CRC) excluded. This overlooked risk is comparable to hypertension.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Fecal immunochemical test (FIT) is for colorectal cancer (CRC) screening. Its association with non-CRC mortality has been overlooked. Given the quantitative FIT values, its dose-response relationships with different causes of deaths and years of life shortened were assessed. METHODS: Th...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejim.2023.09.023

データ提供：米国国立医学図書館（NLM）

Positive Fecal Immunochemical Test: A Silent Warning?

Colorectal cancer (CRC) screening is a vital tool for early detection and prevention. The fecal immunochemical test (FIT) is a commonly used screening method, detecting traces of blood in the stool. This study delves into the surprising association between positive FIT results and increased mortality from various causes, not just CRC. The researchers embarked on a detailed analysis, uncovering a dose-response relationship between FIT values and mortality risk.

A Deeper Dive into Mortality Risk

The study found that positive FIT results were associated with a significant increase in all-cause mortality, including cancer-related deaths, even after excluding CRC. This unexpected discovery highlights a broader picture of health risks associated with positive FIT results.

Beyond Colon Cancer

This research underscores the importance of considering the potential implications of positive FIT results beyond CRC. The study suggests that individuals with positive FIT results, even after a negative colonoscopy, should undergo a comprehensive evaluation of their cardiovascular risk factors and be screened for other gastrointestinal cancers.

Dr.Camel's Conclusion

This study, like a mirage in the desert, reveals a hidden threat associated with positive FIT results. It underscores the crucial role of comprehensive assessments and follow-up care, ensuring that individuals receive the appropriate medical attention and preventative measures.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-30
Further Info :

Pubmed ID

37777425

DOI: Digital Object Identifier

10.1016/j.ejim.2023.09.023

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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