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Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression.

Author: , BitterIstvan, BuyzeJozefien, CebullaKerstin, FreyRichard, FuDong-Jing, GodinovYordan, ItoTetsuro, KambarovYerkebulan, LlorcaPierre-Michel, MesserThomas, Mulhern-HaugheySiobhán, Oliveira-MaiaAlbino J, ReifAndreas, RiveBenoît, YoungAllan H, von HoltChristian

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study looked at the effectiveness and safety of esketamine nasal spray and extended-release quetiapine for treatment-resistant depression.
Paper Details　
Original Abstract of the Article :
In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage of patients with remission is low and the percentage with relapse is high. The efficacy and safety of esketamine nasal spray as compar...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa2304145

データ提供：米国国立医学図書館（NLM）

A New Path for Treatment-Resistant Depression: Exploring Esketamine Nasal Spray

Treatment-resistant depression, a challenging mental health condition, often requires exploring innovative approaches to achieve therapeutic breakthroughs. This study investigates the efficacy and safety of esketamine nasal spray as a treatment for treatment-resistant depression, comparing it to extended-release quetiapine augmentation therapy. This research, much like a camel navigating a complex and challenging desert landscape, seeks to find a new path to relief for individuals struggling with this debilitating condition.

A New Oasis of Hope: Esketamine Nasal Spray for Treatment-Resistant Depression

The study's findings offer promising insights into the potential of esketamine nasal spray for managing treatment-resistant depression. This innovative approach, much like a camel discovering a hidden oasis in the desert, provides a potential avenue for achieving therapeutic breakthroughs in cases that have not responded to traditional treatments. The research's findings highlight the need to continue exploring novel therapeutic strategies for addressing this challenging mental health condition.

Navigating the Desert of Depression: Seeking Effective Treatment Solutions

Individuals experiencing treatment-resistant depression should work closely with a mental health professional to discuss appropriate treatment options. It is crucial to explore all available therapies and to find a treatment approach that provides effective and personalized relief. This journey, much like a camel navigating a vast and unpredictable desert, may require exploring various options and strategies to find the most effective path to symptom management and well-being.

Dr.Camel's Conclusion

This study explores the potential of esketamine nasal spray as a treatment for treatment-resistant depression. It's like discovering a new and refreshing oasis in the desert, offering a potential source of relief for those who have struggled to find effective treatment. The research highlights the importance of seeking innovative therapeutic approaches for managing challenging mental health conditions, particularly those that have not responded to traditional treatments. This research, much like a camel's enduring journey through the desert, offers a glimmer of hope for those seeking effective treatment options.

Date :
  1. Date Completed 2023-10-31
  2. Date Revised 2023-10-31
Further Info :

Pubmed ID

37792613

DOI: Digital Object Identifier

10.1056/NEJMoa2304145

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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