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Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells.
Author: Aghamirza Moghim Ali AbadiHooman, GhavamiGhazaleh, MadanchiHamid, Mousavi MalekiMasoumeh Sadat, SardariSoroush, ShabaniAli Akbar, VaziriBehrooz
Original Abstract of the Article :
Enzyme therapy for celiac disease (CeD), which digests gliadin into non-immunogenic and non-toxic peptides, can be an appropriate treatment option for CeD. Here, we have investigated the effectiveness of bromelain and ficin on gliadin digestion using in vitro, such as SDS-PAGE, HPLC, and circular di...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s00726-023-03333-x
データ提供:米国国立医学図書館(NLM)
Bromelain and Ficin: Potential Enzyme Therapy for Celiac Disease
This study explores the potential of [bromelain and ficin], [proteolytic enzymes], as a treatment option for [celiac disease (CeD)]. The researchers investigated the effects of these enzymes on the [digestion of gliadin], a [protein] found in [wheat] that triggers [immune responses] in individuals with [CeD]. They discovered that [bromelain and ficin] effectively [digested gliadin] into [non-immunogenic and non-toxic peptides], reducing its [cytotoxicity] in [Caco-2 cells]. The study highlights the potential of [enzyme therapy] as a promising approach for managing [CeD] symptoms.
Digesting the Challenges of Celiac Disease
This research provides a compelling case for exploring [enzyme therapy] as a treatment option for [CeD]. The study's findings suggest that [bromelain and ficin] can effectively [digest gliadin] into [non-toxic peptides], mitigating its harmful effects on [intestinal cells]. This study, like a desert oasis providing relief from the scorching sun, offers a refreshing perspective on managing [CeD] symptoms.
Hope for Celiac Disease Sufferers
This research offers a ray of hope for individuals with [CeD] by exploring the potential of [enzyme therapy] to manage the debilitating symptoms of this disorder. The study's findings underscore the importance of continued research into alternative treatments for [CeD] to improve the quality of life for those affected. Like a desert traveler seeking solace in a hidden oasis, this research provides a glimmer of hope for those struggling with [CeD] and opens the door to new possibilities for managing this challenging condition.
Dr.Camel's Conclusion
This study explores the potential of [bromelain and ficin] as an [enzyme therapy] for [Celiac disease]. The research highlights the importance of exploring alternative treatment options for managing this challenging condition and underscores the need for continued research in this area. This study, like a desert wind carrying a message of hope, reminds us that even in the midst of challenges, there is always the potential for new discoveries and breakthroughs.
Date :
- Date Completed 2023-12-04
- Date Revised 2023-12-04
Further Info :
Related Literature
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