A mouse model of sleep disorders in Parkinson's disease showing distinct effects of dopamine D2-like receptor activation.

Author: AguiarCleiton Lopes, BoiLaura, FisoneGilberto, MedeirosDaniel de Castro, MendesRenan Viana, MoraesMarcio Flávio Dutra, PisanòClarissa Anna, PlewniaCarina

Paper Details 
Original Abstract of the Article :
Excessive daytime sleepiness (EDS) and sleep fragmentation are often observed in Parkinson's disease (PD) patients and are poorly understood despite their considerable impact on quality of life. We examined the ability of a neurotoxin-based mouse model of PD to reproduce these disorders and tested t...See full text at original site
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引用元:
https://doi.org/10.1016/j.pneurobio.2023.102536

データ提供:米国国立医学図書館(NLM)

A Mouse Model of Sleep Disorders in Parkinson's Disease

This research delves into the complex world of

Parkinson's disease (PD)

, a neurodegenerative disorder that affects millions worldwide. Like a skilled scientist unraveling the mysteries of the brain, researchers developed a mouse model of PD to investigate the underlying mechanisms of sleep disturbances commonly experienced by individuals with this condition. Their findings reveal distinct effects of

dopamine D2-like receptor activation

on sleep patterns, highlighting the role of dopamine signaling in regulating sleep in PD. This research sheds light on the complex interplay between dopamine dysfunction, sleep disturbances, and PD, offering potential avenues for developing more effective treatments for sleep disorders in this population.

Unraveling the Sandstorm of Sleep Disturbances

This study, like a journey through a desert of sleep disturbances, sheds light on the complex interplay between dopamine dysfunction and sleep problems in PD. The researchers' findings reveal the distinct effects of dopamine D2-like receptor activation on sleep patterns, offering valuable insights into the neurobiological mechanisms underlying these disorders. This research underscores the importance of addressing sleep disturbances in PD, not only for improving quality of life but also for potentially mitigating disease progression.

Navigating the Oasis of Restful Sleep

This study provides valuable guidance for navigating the challenges of sleep disturbances in PD. The researchers' findings highlight the role of dopamine signaling in regulating sleep and suggest that targeting dopamine D2-like receptors could offer potential therapeutic avenues for addressing these disorders. This research is a beacon of hope for individuals with PD seeking to improve their sleep and overall well-being.

Dr.Camel's Conclusion

This study underscores the importance of understanding the complex interplay between dopamine dysfunction and sleep disturbances in PD. The researchers' findings offer valuable insights into the neurobiological mechanisms underlying these disorders and suggest potential therapeutic targets for improving sleep in this population. This research is a testament to the ongoing quest to unravel the mysteries of the brain and to develop more effective treatments for neurological disorders.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

37805096

DOI: Digital Object Identifier

10.1016/j.pneurobio.2023.102536

Related Literature

SNS
PICO Info
in preparation
Languages

English

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