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Safety of Single High-Dose Liposomal Amphotericin B for Induction Treatment of Cryptococcal Meningitis and Histoplasmosis in People With HIV: A Systematic Review and Meta-analysis.

Author: BluntHeather B, HoCaroline C, KangHeeEun, MurphyRichard A, PasqualottoAlessandro C, RibletNatalie B, UyJohn P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

A systematic review of three trials involving 946 individuals with HIV-associated cryptococcal meningitis and histoplasmosis found that single, high-dose liposomal amphotericin B (LAmB) was associated with a lower risk of life-threatening adverse events compared to traditional amphotericin B regimens. The risk of grade 3 and 4 adverse events was equivalent between groups, but LAmB had a lower risk of grade 4 adverse events overall, including renal and hematological events.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Evidence for efficacy of single, high-dose liposomal amphotericin B (LAmB) in HIV-associated cryptococcal meningitis and histoplasmosis is growing. No systematic review has examined the safety of this regimen across multiple studies. METHODS: We systematically searched Medline, Scopus, ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551850/

データ提供：米国国立医学図書館（NLM）

A Single Dose of Hope: The Safety of High-Dose Liposomal Amphotericin B

Cryptococcal meningitis and histoplasmosis, serious fungal infections, can be life-threatening, especially for people with HIV. This study examines the safety of a single, high-dose liposomal amphotericin B (LAmB) regimen for treating these infections. The researchers aimed to determine if this new approach is a safe alternative to traditional amphotericin treatments.

A Safe Oasis in a Fungal Storm

The study found that single, high-dose LAmB was associated with a lower risk of life-threatening side effects compared to traditional amphotericin treatments. This is significant because it offers a safer and potentially more effective option for treating these infections. Imagine finding a cool, refreshing oasis in the middle of a raging desert storm.

Hope for Patients with Fungal Infections

This study provides hope for patients with HIV-associated cryptococcal meningitis and histoplasmosis. The findings suggest that a single high-dose LAmB regimen could be a safer and more convenient way to treat these infections.

Dr.Camel's Conclusion

This study offers a significant advancement in the treatment of fungal infections in people with HIV. By demonstrating the safety and potential benefits of a single, high-dose LAmB regimen, this research opens the door for more effective and less burdensome treatment options.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-31
Further Info :

Pubmed ID

37808894

DOI: Digital Object Identifier

PMC10551850

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・Effective treatment of histoplasmosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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