Current insights and molecular docking studies of HIV-1 reverse transcriptase inhibitors.

Author: AroraSahil, EmwasAbdul-Hamid, JaremkoMariusz, KhalilullahHabibullah, KumarAdarsh, KumarPradeep, KumarRaj, SinghAnkit Kumar, VermaAmita

Paper Details 
Original Abstract of the Article :
Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), a lethal disease that is prevalent worldwide. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) data, 38.4 million people worldwide were living with HIV in 2021. Viral reverse transcriptase (RT) i...See full text at original site
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引用元:
https://doi.org/10.1111/cbdd.14372

データ提供:米国国立医学図書館(NLM)

HIV-1 Reverse Transcriptase Inhibitors: A Powerful Weapon Against AIDS

HIV, the virus that causes AIDS, continues to pose a major global health challenge. Reverse transcriptase, a crucial enzyme responsible for the replication of HIV, is a key target for antiviral drugs. This review focuses on two classes of HIV-1 reverse transcriptase inhibitors: nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). The review examines their mechanisms of action, FDA-approved drugs, agents in clinical trials, and their potential for resistance and adverse effects.

Understanding HIV-1 RT Inhibitors: A Vital Component of Antiretroviral Therapy

This review provides a comprehensive overview of HIV-1 reverse transcriptase inhibitors, highlighting their importance in antiretroviral therapy. The review explores the binding sites, mechanisms of action, and clinical significance of these inhibitors, underscoring their role in effectively managing HIV infection. The review also delves into the challenges associated with drug resistance and adverse effects, emphasizing the importance of ongoing research and development of new and improved therapies.

Combating HIV: A Journey Towards a Cure

The development of HIV-1 reverse transcriptase inhibitors has been a major breakthrough in the fight against AIDS. This review, like a compass guiding us through the complexities of HIV treatment, illuminates the progress made in understanding and targeting this crucial enzyme. As we continue to research and develop new therapies, the journey towards a cure for HIV remains a vital pursuit, offering hope to those affected by this global pandemic.

Dr. Camel's Conclusion

Just like a camel traversing a vast desert, researchers are relentlessly seeking a cure for HIV. This review, like a map guiding us through the intricate landscape of HIV treatment, highlights the powerful role of reverse transcriptase inhibitors in combatting this devastating disease. With continued research and development, the journey towards a cure for HIV continues, offering a beacon of hope for those affected by this global pandemic.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-30
Further Info :

Pubmed ID

37817296

DOI: Digital Object Identifier

10.1111/cbdd.14372

Related Literature

SNS
PICO Info
in preparation
Languages

English

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