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CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects.
Author: AtzoriLuigi, CadoniAndrea, DessìMariele, LambertiniMatteo, LeoniVera Piera, PrettaAndrea, ScartozziMario, SolinasCinzia, WekkingDemi
Original Abstract of the Article :
A dysregulated cell division, one of the key hallmarks of cancer, results in uncontrolled cellular proliferation. This aberrant process, mediated by a dysregulated cell-cycle machinery and overactivation of cyclin-dependent kinase (CDK) 4 and 6, can potentially promote tumorigenesis. The clinical ap...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.cytogfr.2023.10.001
データ提供：米国国立医学図書館（NLM）
CDK4/6 Inhibition: A Promising Avenue for Breast Cancer Treatment
The review explores the role of CDK4/6 inhibitors in the treatment of hormone receptor-positive/HER2-negative breast cancer. These inhibitors target key proteins involved in cell cycle regulation, aiming to disrupt uncontrolled cell proliferation, a hallmark of cancer. The review discusses the biological and clinical aspects of CDK4/6 inhibition, highlighting its potential benefits and expanding role in breast cancer treatment.
CDK4/6 Inhibition: A Multifaceted Approach to Breast Cancer Treatment
The review highlights the potential of CDK4/6 inhibitors to effectively treat breast cancer beyond cell cycle arrest. It explores emerging data suggesting their anti-tumor effects, including immunomodulatory activities, impact on metabolic state, and influence on cellular quiescence and senescence. The review also provides an update on clinical trial outcomes and the differences in mechanisms between various CDK4/6 inhibitors.
Breast Cancer Treatment: Navigating New Frontiers in Targeted Therapy
This review underscores the importance of continued research and development of targeted therapies like CDK4/6 inhibitors for breast cancer treatment. It highlights the need for personalized treatment approaches that consider individual factors and optimize treatment outcomes. Consulting with a healthcare professional is essential for understanding available treatment options and making informed decisions about the best course of action for managing breast cancer.
Dr.Camel's Conclusion
Imagine breast cancer as a relentless desert wind, eroding the body's healthy cells. CDK4/6 inhibitors, like a sturdy desert fortress, can help to defend against this relentless force. This review highlights the promise of these inhibitors as a potent weapon in the fight against breast cancer, but remember, like navigating a desert, it's crucial to seek guidance from a skilled expert to ensure the best possible outcome.
Date :
- Date Completed n.d.
- Date Revised 2023-10-14
Further Info :
Related Literature
English
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