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Lenacapavir: A novel injectable HIV-1 capsid inhibitor.

Author: DwyerKeri A Mastro, HitchcockAllison M, KufelWesley D, SidmanEric F

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Lenacapavir is a new drug that inhibits the HIV-1 capsid protein, preventing the virus from replicating. It is given every six months after an initial oral loading dose and has been shown to be effective in treating multidrug-resistant HIV-1 infection. In clinical trials, Lenacapavir was well tolerated with common side effects including mild to moderate injection site reactions, gastrointestinal symptoms, and headache.
Paper Details　
Original Abstract of the Article :
Patients living with multidrug-resistant (MDR) HIV have limited antiretroviral regimen options that provide durable viral suppression. Lenacapavir is a novel first-in-class inhibitor of HIV-1 capsid function with efficacy at various stages of the viral life cycle, and it is indicated for the treatme...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijantimicag.2023.107009

データ提供：米国国立医学図書館（NLM）

Lenacapavir: A Novel Injectable HIV-1 Capsid Inhibitor for Multidrug-Resistant HIV

The fight against multidrug-resistant (MDR) HIV is a relentless battle, like navigating a treacherous desert. This article introduces Lenacapavir, a groundbreaking HIV-1 capsid inhibitor, offering hope for patients with limited treatment options. With its unique mechanism of action and favorable pharmacokinetic profile, Lenacapavir presents a promising new approach for managing MDR HIV-1 infection.

Lenacapavir: A New Weapon in the Fight Against Multidrug-Resistant HIV

Lenacapavir's efficacy against MDR HIV-1 infection, combined with its well-tolerated profile and favorable pharmacokinetics, makes it a promising new treatment option. Think of it as a new breed of camel, adapted to navigate the harsh desert landscape of MDR HIV, offering hope for sustained viral suppression and improved quality of life for those affected.

Navigating the Complexities of Multidrug-Resistant HIV Treatment

This article underscores the ongoing efforts to develop novel and effective treatments for MDR HIV infection. Like exploring a vast and complex desert, research continues to uncover new approaches and therapies, offering hope for those facing the challenges of this formidable disease.

Dr.Camel's Conclusion

Lenacapavir emerges as a hopeful beacon in the fight against multidrug-resistant HIV, offering a potential solution for those navigating the treacherous desert of limited treatment options. This groundbreaking capsid inhibitor represents a significant step forward in the battle against this formidable disease.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-24
Further Info :

Pubmed ID

37844807

DOI: Digital Object Identifier

10.1016/j.ijantimicag.2023.107009

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in preparation
Languages

English

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