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Effects of gestational haloperidol exposure on mRNA expressions related to glutamate and GABA receptors in offspring.

Author: FunahashiYu, IgaJun-Ichi, KumonHiroshi, OchiShinichiro, UenoShu-Ichi, YoshinoYuta

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fetal exposure to haloperidol can affect glutamate and GABA receptors in the brain of offspring mice, with changes in mRNA expression levels in the hippocampus and frontal lobes.
Paper Details　
Original Abstract of the Article :
Antipsychotic treatment is vital for patients with schizophrenia even in the perinatal period, but the impact at the molecular biological level on offspring is unclear. The aim of the present study was to investigate the effects of intraperitoneal haloperidol injection to pregnant mice on glutamate ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582061/

データ提供：米国国立医学図書館（NLM）

Gestational Haloperidol Exposure: A Molecular Desert

Antipsychotic medications are vital for treating mental health conditions, but their use during pregnancy can raise concerns about potential effects on the developing fetus. It's like navigating a desert of uncertainties, wondering about the long-term consequences of exposure to these medications. This study investigates the effects of gestational haloperidol exposure on glutamate and GABA receptors in the brain of offspring mice, exploring the molecular mechanisms at play.

Exploring the Molecular Landscape

The researchers examined the expression levels of genes related to glutamate and GABA receptors, key players in brain function and development. It's like exploring a molecular desert, mapping the intricate pathways and interactions within the brain. The study found that gestational haloperidol exposure significantly affected the expression of these receptors in offspring mice, suggesting potential long-term consequences for brain development and function.

Navigating the Desert of Knowledge

This research adds to our understanding of the potential risks associated with gestational haloperidol exposure. It's like uncovering hidden dangers in a vast and unexplored desert. The study emphasizes the importance of careful consideration and monitoring when prescribing antipsychotic medications during pregnancy. Further research is needed to fully understand the long-term implications of gestational haloperidol exposure and to develop safer alternatives.

Dr.Camel's Conclusion

This study investigates the effects of gestational haloperidol exposure on glutamate and GABA receptors in the brain of offspring mice, exploring the molecular mechanisms at play. This research adds to our understanding of the potential risks associated with gestational haloperidol exposure. The study emphasizes the importance of careful consideration and monitoring when prescribing antipsychotic medications during pregnancy. Further research is needed to fully understand the long-term implications of gestational haloperidol exposure and to develop safer alternatives.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-21
Further Info :

Pubmed ID

37860710

DOI: Digital Object Identifier

PMC10582061

Related Literature

Article Analysis
・Effects of haloperidol injection
SNS
PICO Info
in preparation
Languages

English

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