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Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery.

Author: ChoiHyojoo, JungWoobin, KimBonglee, KimJeongwoo, KimJimin, KimWoojin, NurkolisFahrul

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review explores the potential of plant extracts for treating Polycystic Ovary Syndrome (PCOS). 72 studies on natural products were analyzed, revealing that certain plant-derived chemicals can reduce inflammation by controlling the PI3K/AKT signaling pathway and decreasing NF-κB and cytokines. Other extracts normalize hormones by altering the HPO axis and reduce oxidative stress by increasing glutathione, superoxide dismutase, catalase, and glutathione peroxidase levels. Additionally, some plant components prevent autophagy by impairing beclin 1, ATG5, and LC3-II. These findings suggest that plant extracts could be valuable natural bio-resources for PCOS treatment by regulating inflammation, hormones, reactive oxygen species, and autophagy.
Paper Details　
Original Abstract of the Article :
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder with a worldwide prevalence of 6-10 % of women of reproductive age. PCOS is a risk factor for cardiometabolic disorders such as type 2 diabetes, myocardial infarction, and stroke in addition to exhibiting signs of hyperandrogenism and a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589870/

データ提供：米国国立医学図書館（NLM）

Harnessing Nature's Power: Natural Products for Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. While conventional treatments often target symptoms with various adverse effects, this review explores the potential of natural products derived from plants to address PCOS. The authors reviewed 72 studies focusing on natural products with potential benefits for PCOS. Their analysis revealed that certain plant extracts could effectively reduce inflammation, normalize hormonal imbalances, and mitigate oxidative stress associated with PCOS. These effects are attributed to various mechanisms, including modulation of key signaling pathways, regulation of hormone levels, and enhancement of antioxidant defenses.

Finding Balance in the Desert of PCOS: Nature's Solutions

This review highlights the potential of natural products to provide a more holistic approach to managing PCOS, addressing multiple aspects of the disorder. The authors' thorough analysis of existing research provides a valuable roadmap for future studies exploring the therapeutic potential of natural remedies for PCOS. This approach offers hope for more natural and potentially less burdensome treatment options for women living with this complex condition.

Navigating the Desert of PCOS with Nature's Guidance

The journey through the desert of PCOS can be challenging, marked by hormonal imbalances, inflammation, and oxidative stress. This review offers a beacon of hope, highlighting the potential of natural products to provide solace and relief. The research suggests that nature holds a rich treasure trove of potential solutions for managing PCOS, providing a path toward a more balanced and healthier life.

Dr. Camel's Conclusion

This comprehensive review underscores the promising potential of natural products in addressing PCOS. By harnessing nature's wisdom, we can unlock new avenues for managing this complex condition, offering a path towards more natural and effective treatments.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-31
Further Info :

Pubmed ID

37867816

DOI: Digital Object Identifier

PMC10589870

SNS
PICO Info
in preparation
Languages

English

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