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Single-cell transcriptomics uncover hub genes and cell-cell crosstalk in patients with hypertensive nephropathy.

Author: DingXiang, EggenhuizenPeter J, HuXueling, JinPeng, LinWei, MengTing, OoiJoshua D, ShenChanjuan, TangRong, XiaoXiangcheng, YuLeilin, ZhangLinlin, ZhongYong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated gene expression profiles of renal biopsy samples from patients with hypertensive nephropathy (HTN) using single-cell RNA sequencing. The results highlight distinct cell-specific gene expression profiles, pathogenic inflammatory signaling pathways, and potential cell-cell communications between different renal cell types. These findings offer insights into the mechanisms of HTN and potential targets for treatment.
Paper Details　
Original Abstract of the Article :
Hypertensive nephropathy (HTN) is one of the leading causes of end-stage renal disease, yet the molecular mechanisms are still unknown. To explore novel mechanisms and gene targets for HTN, the gene expression profiles of renal biopsy samples obtained from 2 healthy living donor controls and 5 HTN p...See full text at original site
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引用元：
https://doi.org/10.1016/j.intimp.2023.111104

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Hypertensive Nephropathy

Hypertensive nephropathy (HTN), a condition that affects the kidneys, is like a desert oasis that's slowly being overtaken by encroaching sand dunes. This research explores the molecular mechanisms underlying this condition, hoping to understand the desert's delicate ecosystem and find ways to combat the encroaching sands.

The study used single-cell RNA sequencing to analyze gene expression profiles in renal biopsy samples from patients with HTN. The researchers identified distinct cell-specific gene expression patterns, revealing the intricate dance of cells within the kidneys. This is like mapping the intricate network of plants and animals within the oasis, uncovering their roles and interactions.

The study found that HTN endothelium showed an upregulation of genes related to cellular adhesion, inflammation, and apoptosis. These changes highlight the potential role of endothelial dysfunction in HTN progression. In the proximal tubules, the researchers identified hub genes that could be potential targets for future therapies.

New Insights into HTN

This study offers new insights into the molecular mechanisms underlying HTN, providing a roadmap for understanding this complex condition. This is like discovering a hidden spring in the desert, offering a new source of water for the oasis and a chance for growth and renewal.

A Glimpse into a Complex Ecosystem

The study highlights the complexity of the renal system and the need for further research to develop effective treatments for HTN. It's like studying the intricate dance of life within a desert oasis, understanding the delicate balance that ensures its survival.

Dr. Camel's Conclusion

This study provides a deeper understanding of the cellular processes involved in HTN, offering potential targets for future therapies. It's like discovering a hidden oasis, a place of hope and potential for restoring balance and health in the desert of disease.

Date :
  1. Date Completed 2023-11-20
  2. Date Revised 2023-11-29
Further Info :

Pubmed ID

37897949

DOI: Digital Object Identifier

10.1016/j.intimp.2023.111104

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in preparation
Languages

English

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