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Pharmacogenetic Approach for the Prevention of Rivaroxaban's ADRs: A Systematic Review and Meta-Analysis.

Author: AbbasiBahareh, AfsharmoghaddamTara, MardiParham, ShafieeArman

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This systematic review and meta-analysis found that the ABCB1 gene variant rs1045642 is associated with higher rivaroxaban levels. Identifying this genetic variant before administering rivaroxaban may help reduce adverse drug reactions.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Pharmacogenetics is a potential approach that can be applied to decline the burden of rivaroxaban's ADRs. The current systematic review and meta-analysis aim to identify genetic variants correlated with rivaroxaban exposure and evaluate their importance. METHODS: We systematically sea...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630013/

データ提供：米国国立医学図書館（NLM）

Pharmacogenetics and Rivaroxaban: Tailoring Treatment to Individual Needs

In the realm of personalized medicine, pharmacogenetics is a powerful tool for tailoring treatment to an individual's genetic makeup. This study focuses on the use of pharmacogenetics to prevent adverse drug reactions (ADRs) associated with rivaroxaban, a blood thinner commonly used for stroke prevention. The researchers conducted a systematic review and meta-analysis to identify genetic variants linked to rivaroxaban exposure and ADRs.

Uncovering Genetic Predictors of Rivaroxaban Metabolism

The study revealed that specific variants of the ABCB1 and APOB genes were significantly correlated with rivaroxaban concentrations. This is similar to finding different types of cacti that thrive in specific desert environments, each with unique genetic adaptations. The variant rs1045642 of the ABCB1 gene, in particular, was identified as a potential predictor of rivaroxaban metabolism, suggesting that identifying this variant before drug administration could help minimize ADRs.

Towards a Safer Future of Blood Thinners

This research provides a valuable foundation for optimizing rivaroxaban therapy. The findings suggest that integrating pharmacogenetic testing into clinical practice could lead to more personalized and safer treatment strategies. It's a reminder that just as a desert traveler must adapt their journey based on the terrain, so too must we adapt our medical practices to the unique genetic landscape of each individual.

Dr. Camel's Conclusion

This study underscores the potential of pharmacogenetics for improving patient safety and efficacy of rivaroxaban therapy. It's a testament to the advancements in personalized medicine, offering a glimpse into a future where treatment is tailored to individual needs. Just as a desert nomad relies on their knowledge of the environment to navigate safely, so too must we continue exploring the vast and ever-changing world of genetics to optimize healthcare for all.
Date :
  1. Date Completed 2023-11-10
  2. Date Revised 2023-11-10
Further Info :

Pubmed ID

37942082

DOI: Digital Object Identifier

PMC10630013

Related Literature

Article Analysis
・Side Effects of rivaroxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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