Acrofacial vitiligo secondary to PI3KCA inhibitor, alpelisib: case report.

Author: HijabAdham, HinichMaayan Geller

Paper Details 
Original Abstract of the Article :
Alpelisib plus fulvestrant is a valid second or advanced line of treatment for patients with metastatic hormone receptor (HR)-positive, HER2-negative breast cancer who harbor an activating PIK3CA mutation. The well-known side effects of alpelisib are hyperglycemia, rash, and diarrhea. Herein, we rep...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642942/

データ提供:米国国立医学図書館(NLM)

Alpelisib and the Unexpected Side Effect of Vitiligo

Alpelisib, a medication used for treating certain types of breast cancer, is generally well-tolerated, but can sometimes cause unexpected side effects. This case report describes an unusual instance of a patient developing acrofacial vitiligo, a condition characterized by depigmentation of the skin, after starting treatment with alpelisib. This finding raises important questions about the potential dermatological side effects of alpelisib and the need for careful monitoring of patients undergoing treatment with this medication.

Alpelisib and the Potential for Vitiligo

This case report highlights the importance of being vigilant about potential side effects of medications, even those considered relatively safe. The patient's development of acrofacial vitiligo after starting alpelisib suggests a possible link between the medication and this dermatological condition. Further research is needed to confirm this association and to better understand the mechanisms underlying this side effect.

Navigating the Treatment of Breast Cancer

As a doctor, I understand the importance of balancing treatment effectiveness with potential side effects. This case report reminds us that even medications considered safe can have unexpected consequences. It emphasizes the need for open communication between doctors and patients, ensuring that patients are fully informed about potential risks and benefits of their treatment options.

Dr.Camel's Conclusion

Alpelisib, a medication used to combat breast cancer, is like a desert oasis offering hope for patients. However, like the unpredictable desert, sometimes unexpected challenges arise. This case report reminds us to be observant, just as a camel navigates the desert, and to remain vigilant for potential side effects, ensuring the best outcomes for our patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-16
Further Info :

Pubmed ID

37965451

DOI: Digital Object Identifier

PMC10642942

Related Literature

SNS
PICO Info
in preparation
Languages

English

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