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SAR-096: Phase II clinical trial of ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma (DDL), and leiomyosarcoma (LMS).
Author: BarkerEmma, CaiKathy Q, ChoyEdwin, FliederDouglas B, GeorgeSuzanne, HandorfElizabeth A, MatloobSahar, MerriamPriscilla, MovvaSujana, PaganCheyenne, RinkLori, TetzlaffEric D, VeggebergRosanna, ZhouYan, ZumpanoDelia, von MehrenMargaret
Original Abstract of the Article :
DDL and LMS are two common subtypes of soft tissue sarcoma, a rare group of diseases for which new treatments are needed. Chemotherapy remains the standard option for advanced disease. Targeting CDK4/6 in DDL and mTOR in LMS is of biologic interest. When combined, the CDK4 inhibitor ribociclib and t...See full text at original site
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引用元：
https://doi.org/10.1158/1078-0432.CCR-23-2469
データ提供：米国国立医学図書館（NLM）
A New Combination Therapy for Soft Tissue Sarcoma
Soft tissue sarcoma, a rare type of cancer, poses a significant challenge for treatment. This study explores a new combination therapy for [dedifferentiated liposarcoma (DDL)] and [leiomyosarcoma (LMS)], two common subtypes of [soft tissue sarcoma]. The researchers investigated the potential of combining [ribociclib], a [CDK4 inhibitor], and [everolimus], an [mTOR inhibitor], to target key pathways involved in tumor growth. Preclinical studies have shown synergistic growth inhibition with this combination, suggesting a promising new approach for treating these challenging cancers.
A Promising New Approach for Soft Tissue Sarcoma
The study's findings offer hope for patients with [DDL] and [LMS], highlighting the potential of [ribociclib] and [everolimus] combination therapy to improve treatment outcomes. The synergistic effect of these two drugs could lead to more effective tumor control and potentially improve patient survival. Further clinical trials are needed to confirm the efficacy and safety of this combination therapy.
A New Oasis in the Desert of Cancer Treatment
This study offers a glimmer of hope in the ongoing fight against [soft tissue sarcoma]. It's a testament to the power of scientific innovation and the ongoing search for new and effective treatments for challenging diseases. Just as a camel can find life-sustaining oases in the harsh desert, this research offers a potential source of hope for patients seeking new and effective treatments for [soft tissue sarcoma].
Dr.Camel's Conclusion
This study highlights the promise of combining different therapeutic approaches to target cancer cells more effectively. It's a reminder that even in the face of challenging diseases like [soft tissue sarcoma], ongoing research and innovative treatments offer hope for a brighter future. Just as a camel navigates the desert with perseverance, researchers continue to explore new frontiers in cancer research, seeking to find the most effective and compassionate solutions for patients.
Date :
- Date Completed n.d.
- Date Revised 2023-11-15
Further Info :
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