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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats.
Author: GeBi-Ying, HongJau-Shyong, JinLing-Ling, LiSheng, LiuYing-Xin, WangQing-Shan, WangYan-Fang, WangYing, YangJing-Jing, YinSheng-Ming, ZhangJian-Jie, ZhaoJie
Original Abstract of the Article :
Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy (TLE). We postulated that kainic acid (KA)-Induced status epilepticus triggers microglia-dependent inflammation, leading to neuronal damage, a lowered seizure threshol...See full text at original site
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引用元:
https://doi.org/10.1007/s12264-023-01140-8
データ提供:米国国立医学図書館(NLM)
Ultra-Low Dose Dextromethorphan: A Novel Approach to Epilepsy
Epilepsy, a neurological disorder characterized by recurrent seizures, is a complex and challenging condition. This research explores the potential benefits of ultra-low dose dextromethorphan, a common over-the-counter cough suppressant, in treating chronic temporal lobe epilepsy (TLE). The authors investigated the effects of dextromethorphan on kainic acid-induced TLE in rats, finding that it significantly mitigated seizure frequency, improved cognitive function, and reduced hippocampal neuronal loss. The study suggests that dextromethorphan may have neuroprotective and anti-epileptic properties, offering a potential new avenue for treatment.
Beyond the Cough Syrup: Dextromethorphan's Potential
This research sheds light on the potential therapeutic applications of dextromethorphan beyond its traditional use as a cough suppressant. The study's findings suggest that even at ultra-low doses, dextromethorphan can have neuroprotective and anti-epileptic effects, offering a promising avenue for treating chronic temporal lobe epilepsy.
A Desert of Hope for Epilepsy Patients
Epilepsy can be a life-altering condition, but research continues to uncover new and innovative treatment strategies. This study suggests that dextromethorphan, a commonly available medication, may hold promise for treating chronic temporal lobe epilepsy. Further research is needed to confirm these findings and explore the potential of dextromethorphan as a safe and effective treatment option.
Dr.Camel's Conclusion
This research offers a fascinating glimpse into the potential of a seemingly ordinary medication, dextromethorphan, in treating a complex neurological condition like epilepsy. The study's findings provide a beacon of hope for researchers and patients alike, highlighting the importance of exploring new and unexpected avenues in the search for better treatments.
Date :
- Date Completed n.d.
- Date Revised 2023-11-16
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