Efficacy and Safety of MAO-B Inhibitors Safinamide and Zonisamide in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Author: Abou-SettaAhmed, AboulattaLaila, AskinNicole, EltonsySherif, HaidarLara, LavuAlekhya, PeymaniPayam, RabbaniRasheda, ZarychanskiRyan

Paper Details 
Original Abstract of the Article :
In Parkinson's disease, safinamide and zonisamide are novel monoamine oxidase-B inhibitors with a dual mechanism of action involving the inhibition of sodium and calcium channels and the subsequent release of glutamate. The aim of this systematic review and meta-analysis was to examine the efficacy ...See full text at original site
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引用元:
https://doi.org/10.1007/s40263-023-01048-x

データ提供:米国国立医学図書館(NLM)

MAO-B Inhibitors for Parkinson's Disease: A New Oasis in the Desert of Neurological Disorders

The desert of neurological disorders can be a daunting place to explore. Parkinson's disease, a progressive neurodegenerative disorder, can significantly impact a person's quality of life. This research investigates the efficacy and safety of two novel MAO-B inhibitors, safinamide and zonisamide, in the treatment of Parkinson's disease. The researchers conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the potential benefits of these drugs in managing motor symptoms, cognitive function, and quality of life in patients with Parkinson's disease.

A Glimpse of Hope for Parkinson's Disease

This research provides a comprehensive overview of the potential benefits and safety of MAO-B inhibitors, safinamide and zonisamide, in the treatment of Parkinson's disease. The authors conclude that both drugs show promise in improving motor symptoms and quality of life in patients with Parkinson's disease, offering a ray of hope in the desert of neurological disorders.

Navigating the Desert of Parkinson's Disease

The desert of Parkinson's disease can be a challenging journey. If you or a loved one is living with Parkinson's disease, it is essential to seek professional help and explore available treatment options. This research highlights the potential of MAO-B inhibitors, safinamide and zonisamide, as promising new treatments for Parkinson's disease, offering hope for those seeking relief in the desert of neurological disorders.

Dr.Camel's Conclusion

This research, like a refreshing spring in the desert of neurological disorders, offers hope for patients with Parkinson's disease. It underscores the importance of continued research and development of new and effective treatments for this debilitating condition.

Date :
  1. Date Completed 2023-11-24
  2. Date Revised 2023-11-24
Further Info :

Pubmed ID

37973769

DOI: Digital Object Identifier

10.1007/s40263-023-01048-x

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English

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