Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.

Author: De MartinSara, FerriNicola, FolliFranco, GuidettiClotilde, InturrisiCharles E, ManfrediPaolo L, MattareiAndrea, O'GormanCedric, PappagalloMarco, StuartJames, TraversaSergio

Paper Details 
Original Abstract of the Article :
Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker with higher affinity for GluN2D subtypes. Esmethadone showed robust, rapid, and...See full text at original site
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引用元:
https://doi.org/10.1007/s40268-023-00450-6

データ提供:米国国立医学図書館(NLM)

Esmethadone: A New Oasis in the Desert of Depression

The field of [major depressive disorder (MDD)] is a challenging desert, where patients experience profound sadness and hopelessness. This research explores the potential of [esmethadone] as a novel treatment for [MDD], seeking a new oasis of relief in the desert of despair. The authors investigated the drug-drug interactions of [esmethadone] with other medications, seeking to ensure its safe and effective use in treating [MDD].

A New Wellspring of Hope: Esmethadone Shows Promise for MDD

The study found that [esmethadone] showed robust, rapid, and sustained antidepressant effects in patients with [MDD] who had not responded to other antidepressants, offering a new wellspring of hope in the desert of depression. The authors highlight the potential of [esmethadone] to provide relief for those who have struggled to find effective treatments, offering a new path towards a more fulfilling and meaningful life.

Navigating the Desert of Depression: Finding Effective and Safe Treatments

This research underscores the importance of continuing to explore new and innovative treatments for [MDD], seeking a more effective and personalized approach to this debilitating condition. The authors remind us that the desert of depression can be navigated with careful research, innovation, and a commitment to finding the right treatment for each patient. It's a reminder that even in the face of seemingly insurmountable challenges, there is always hope for a better tomorrow.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the vast desert of depression, providing a new oasis of relief for those who have struggled to find effective treatments. Esmethadone shows promise as a potential treatment for [MDD], offering a new path towards a more fulfilling and meaningful life.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-27
Further Info :

Pubmed ID

38010591

DOI: Digital Object Identifier

10.1007/s40268-023-00450-6

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Article Analysis
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PICO Info
in preparation
Languages

English

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