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Antifungal resistance, combinations and pipeline: oh my!

Author: BarberKatie E, CretellaDavid A, HawkinsBrandon K, KeckJ Myles, StoverKayla R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the need for novel antifungal therapies to address rising fungal resistance, particularly in Candida spp., and highlights the potential of new agents such as fosmanogepix, ibrexafungerp, olorofim, and rezafungin.
Paper Details　
Original Abstract of the Article :
Invasive fungal infections are a strong contributor to healthcare costs, morbidity and mortality, especially amongst hospitalized patients. Historically, <i>Candida</i> was responsible for approximately 15% of all nosocomial bloodstream infections. In the past 10 years, the epidemiology of <i>Candid...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653594/

データ提供：米国国立医学図書館（NLM）

Antifungal Resistance: A Growing Challenge in Healthcare

This article provides a comprehensive overview of the challenges posed by antifungal resistance, highlighting the increasing prevalence of resistant fungal pathogens and the urgent need for novel antifungal therapies. The authors explore the current landscape of antifungal resistance, the limitations of existing treatment options, and the potential of new antifungal agents in the pipeline.

A Growing Need for Innovation: Tackling Antifungal Resistance

The study emphasizes the increasing prevalence of resistant Candida spp., a major contributor to nosocomial bloodstream infections. With rising resistance, the demand for novel antifungal therapies has become paramount. The article explores the potential of new antifungal agents like fosmanogepix, ibrexafungerp, olorofim, and rezafungin to address the growing challenge of multidrug-resistant fungal pathogens.

A Camel's Perspective: Navigating the Shifting Sands of Infection

Just as a camel navigates the ever-shifting sands of the desert, healthcare professionals are facing the evolving landscape of antifungal resistance. This article provides valuable insights into the challenges posed by resistant fungal pathogens and the urgent need for innovative treatment strategies. Understanding the complexities of antifungal resistance is crucial for ensuring effective treatment and preventing the spread of infections.

Dr.Camel's Conclusion

This article highlights the growing challenge of antifungal resistance in healthcare. The emergence of multidrug-resistant fungal pathogens necessitates the development of new therapies and innovative treatment strategies. By fostering research and development in this area, we can equip healthcare professionals with the tools necessary to combat this formidable threat.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-01
Further Info :

Pubmed ID

38021410

DOI: Digital Object Identifier

PMC10653594

Related Literature

Article Analysis
・Effects of ibrexafungerp
SNS
PICO Info
in preparation
Languages

English

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