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Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer.

Author: DuGuangsheng, GongTao, HeChunting, LiuRong, MaCheng, SunXun, WangHairui, XieZhiqiang, XuYanhua, YangXiaojia, ZhangYongshun, ZhongXiaofang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a novel approach using cell-penetrating peptide modified oxaliplatin prodrug liposomes and low-dose BCG co-delivered via a viscous chitosan solution (LRO-BCG/CS) to treat non-muscle invasive bladder carcinoma. This approach significantly improved the retention and permeability of chemotherapy agents in the bladder, leading to superior anti-tumor efficacy and prolonged survival time in a bladder tumor model.
Paper Details　
Original Abstract of the Article :
To reduce recurrence rate after transurethral resection of bladder tumor, long-term intravesical instillations of Bacillus Calmette-Guérin (BCG) and/or chemotherapeutic drugs is the standard treatment for non-muscle invasive bladder carcinoma. However, the main challenges of intravesical therapy, su...See full text at original site
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引用元：
https://doi.org/10.1016/j.jconrel.2023.11.050

データ提供：米国国立医学図書館（NLM）

Chemo-Immunotherapy for Bladder Cancer

The fight against bladder cancer is a complex and challenging battle. This study explores a novel approach to treating non-muscle invasive bladder carcinoma, combining chemotherapy with immunotherapy. The researchers developed a co-delivery system that combines oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin (BCG) to enhance the effectiveness of treatment. This innovative approach aims to improve drug retention time, increase permeability across the bladder wall, and activate the immune system to fight the cancer.

A Promising New Approach

The study's findings are like a beacon of hope in the desert of bladder cancer research. The researchers have developed a novel strategy that combines chemotherapy and immunotherapy to enhance treatment effectiveness. This approach, which uses a co-delivery system to improve drug retention and permeability, could revolutionize the treatment of non-muscle invasive bladder carcinoma. The study's results show significant improvements in tumor control and survival rates, offering new hope for patients facing this challenging disease.

A Holistic Approach to Treatment

The study highlights the importance of a holistic approach to cancer treatment, combining chemotherapy and immunotherapy to achieve optimal results. This approach is like a desert caravan, with each element working together to reach a shared destination. The study's findings are a testament to the power of innovation and collaboration in the field of cancer research. As we continue to explore new and effective treatment strategies, we can offer better outcomes for patients with bladder cancer and other challenging diseases.

Dr.Camel's Conclusion

This research is like a camel caravan venturing into a new territory, seeking to find better ways to combat bladder cancer. The study's approach, combining chemotherapy and immunotherapy, offers a beacon of hope for patients facing this challenging disease. The co-delivery system developed by the researchers is an innovative strategy that has the potential to revolutionize treatment and improve outcomes. This is a testament to the power of innovation and collaboration in the fight against cancer.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-07
Further Info :

Pubmed ID

38042374

DOI: Digital Object Identifier

10.1016/j.jconrel.2023.11.050

SNS
PICO Info
in preparation
Languages

English

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