Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: Clinical Relevance, Impact on Outcome, Preventive Measures and Treatment Strategies.

Author: BucelliCristina, CattaneoDaniele, IurloAlessandra, PassamontiFrancesco, SpallarossaPaolo

Paper Details 
Original Abstract of the Article :
The introduction of TKIs into the therapeutic armamentarium of CML has changed the disease paradigm, increasing long-term survival from 20% to over 80%, with a life expectancy now approaching that of the general population. Although highly effective, TKIs also have a toxicity profile that is often m...See full text at original site
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引用元:
https://doi.org/10.1007/s11864-023-01149-1

データ提供:米国国立医学図書館(NLM)

Navigating the Cardiovascular Terrain of Chronic Myeloid Leukemia Treatment

The introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of chronic myeloid leukemia (CML), dramatically increasing survival rates. However, like a shimmering mirage in the desert, TKIs can sometimes come with side effects, including cardiovascular adverse events (AEs). This study delves into the complexities of cardiovascular AEs associated with TKIs, exploring their clinical significance, impact on treatment outcomes, and potential preventive measures. The authors emphasize the need for personalized preventive and therapeutic strategies to manage these potential risks and improve patient outcomes.

Balancing the Benefits and Risks of TKIs

While TKIs are highly effective in controlling CML, their potential cardiovascular side effects must be carefully monitored and managed. The study highlights the importance of a multidisciplinary approach, involving hematologists, cardiologists, and other healthcare professionals to comprehensively assess cardiovascular risk factors and implement appropriate preventive measures. The authors also underscore the significance of individualizing TKI therapy, tailoring treatment to each patient's needs and potentially adjusting doses to minimize side effects.

A Journey Through the Desert of CML Treatment

Navigating the treatment landscape of CML involves a delicate balance between achieving therapeutic goals and minimizing potential risks. This study provides valuable insights into the cardiovascular implications of TKI therapy, emphasizing the importance of early detection, risk factor management, and personalized treatment approaches. As a wise camel, I always encourage proactive healthcare management, just as I would prepare carefully for a long trek through the desert, ensuring my well-being every step of the way.

Dr. Camel's Conclusion

The treatment of CML has made remarkable strides with the advent of TKIs, but these life-saving medications can sometimes come with cardiovascular side effects. This study emphasizes the crucial need for vigilance and personalized approaches to manage these risks. By working closely with healthcare professionals, patients can navigate the challenges of CML treatment, ensuring their overall health and well-being. Remember, like a resilient camel traversing the desert, we must adapt and adjust our course to overcome obstacles and achieve lasting success.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-04
Further Info :

Pubmed ID

38047977

DOI: Digital Object Identifier

10.1007/s11864-023-01149-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

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