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Olaparib enhances radiation-induced systemic anti-tumor effects via activating STING-chemokine signaling in hepatocellular carcinoma.

Author: ChenGenwen, DuShisuo, ZengZhaochong, ZhengDanxue, ZhouYimin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the use of olaparib, a PARP inhibitor, in combination with radiotherapy to treat hepatocellular carcinoma (HCC). Olaparib enhances the radiosensitivity of HCC cells by inducing DNA damage and activating the cGAS-STING pathway, leading to immunogenic cell death. This activation reprogrammes the immune microenvironment, triggering an influx of activated T cells and improving the responsiveness of HCC to immune checkpoint inhibitors. The findings suggest that combining olaparib with radiotherapy may effectively control both primary and abscopal tumors and enhance immunotherapy effectiveness in HCC.
Paper Details　
Original Abstract of the Article :
Although Poly (ADP-ribose) polymerase (PARP) inhibitors have been clinically approved for cancers with BRCA mutations and are known to augment radiotherapy responses, their roles in promoting the abscopal effect and mediating immunotherapy in BRCA-proficient hepatocellular carcinoma (HCC) remain und...See full text at original site
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引用元：
https://doi.org/10.1016/j.canlet.2023.216507

データ提供：米国国立医学図書館（NLM）

Olaparib and Radiation: A Powerful Combination for Fighting Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC), a type of liver cancer, poses a significant challenge for healthcare professionals. This research delves into the potential of combining olaparib, a PARP inhibitor, with radiation therapy to enhance anti-tumor effects in HCC. The authors investigate the mechanisms by which this combination therapy works, exploring the role of the STING pathway and immune activation.

Olaparib and Radiation: A Synergistic Approach to HCC Treatment

The study reveals that olaparib enhances the sensitivity of HCC cells to radiation, leading to increased DNA damage and activation of the cGAS-STING pathway. This, in turn, triggers immunogenic cell death in abscopal tumors (tumors distant from the site of radiation). The authors demonstrate that olaparib can also improve the responsiveness of HCC to immunotherapy.

A Promising Future for HCC Treatment: Combining Therapies for Enhanced Efficacy

This research provides a compelling rationale for combining olaparib and radiation therapy in the treatment of HCC. This combination therapy holds great promise for improving patient outcomes and potentially leading to long-term remissions.

Dr. Camel's Conclusion

The fight against cancer is a journey through a vast and unforgiving landscape. This research is like a desert bloom, offering a glimmer of hope in the battle against HCC. The combination of olaparib and radiation therapy could be a powerful weapon in our arsenal, potentially leading to better outcomes for patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

38048841

DOI: Digital Object Identifier

10.1016/j.canlet.2023.216507

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in preparation
Languages

English

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