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Managing side effects: guidance for use of immunotherapies in multiple myeloma.

Author: LiangEmily C, SidanaSurbhi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review provides an overview of toxicities associated with novel immunotherapies for multiple myeloma, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), delayed neurotoxicity, cytopenias, and infection. It also discusses management recommendations, including the use of tocilizumab, steroids, and anakinra.
Paper Details　
Original Abstract of the Article :
Chimeric antigen receptor T-cell therapy and bispecific T-cell recruiting antibodies have transformed the treatment landscape for relapsed/refractory multiple myeloma, with B-cell maturation antigen being the most common target and other targets in clinical development. However, these therapies are ...See full text at original site
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引用元：
https://doi.org/10.1182/hematology.2023000435

データ提供：米国国立医学図書館（NLM）

Managing side effects: guidance for use of immunotherapies in multiple myeloma

This study explores the exciting world of immunotherapy, a new frontier in the treatment of multiple myeloma, a cancer that affects the bone marrow. The researchers are specifically interested in the challenges associated with managing the side effects of novel immunotherapies used to treat this disease. They embark on a journey to understand the complex side effects of these promising new therapies, seeking to provide guidance on their safe and effective use.

What are the side effects of immunotherapy in multiple myeloma treatment?

The researchers found that while immunotherapies hold great promise for treating multiple myeloma, they can also be associated with severe side effects, like navigating a desert with unpredictable weather patterns. These side effects include cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), delayed neurotoxicity, cytopenias, and infection. The researchers also highlighted the challenge of diagnosing and treating immune effector cell-associated hemophagocytic lymphohistiocytosis (IEC-HS), a complex condition that shares features with CRS and HLH.

Ensuring the safe and effective use of immunotherapy

This study emphasizes the importance of carefully managing the side effects of immunotherapies in multiple myeloma treatment. It's like navigating a desert with a skilled guide who can help you avoid potential hazards. The researchers provide valuable guidance on the management of these side effects, encouraging a multidisciplinary approach to care.

Dr.Camel's Conclusion

This study is a reminder that even with groundbreaking new treatments like immunotherapy, there are still challenges to overcome. The researchers have provided valuable insights into the side effects of these therapies and how to manage them effectively. It's a testament to the ongoing quest for safer and more effective treatments for complex diseases.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-09
Further Info :

Pubmed ID

38066898

DOI: Digital Object Identifier

10.1182/hematology.2023000435

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Article Analysis
・Side Effects of anakinra
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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