Paper Details

  1. Home
  2. Paper Details

A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers.

Author: BatraAmanjot, PergolizziJoseph V, SchmidtWilliam K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A novel formulation of ketorolac tromethamine (NTM-001) delivered as a bolus followed by continuous infusion showed promising results in a first-in-man study for postoperative pain management. Pharmacokinetic parameters and pain relief scores aligned well with the target profile, demonstrating potential for an alternative to opioids. Both treatments were well-tolerated.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: There is an urgent unmet medical need for a safe, effective, nonopioid analgesic agent for postoperative pain control. METHODS: This first-in-man study was designed to explore a data-informed, model-based candidate dosage regimen and safety of a novel formulation of ketorolac trometha...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s12325-023-02709-5

データ提供：米国国立医学図書館（NLM）

A Novel Formulation of Ketorolac for Postoperative Pain Management

This study delves into the realm of pain management, specifically focusing on the search for safe and effective non-opioid analgesics for postoperative pain. The researchers evaluated a novel formulation of ketorolac tromethamine (NTM-001), a non-opioid pain reliever, delivered via a continuous intravenous infusion. This research aims to offer a potential alternative to opioid-based pain management, which can come with undesirable side effects.

A Promising Alternative to Opioids

The study demonstrated the safety and efficacy of NTM-001 as a potential alternative to opioids for postoperative pain control. The novel formulation achieved comparable pain relief to traditional bolus dosing of ketorolac while maintaining a favorable safety profile.

Improving Pain Management Strategies

This research offers a promising new approach to pain management, potentially reducing the reliance on opioids and their associated risks. The development of safe and effective non-opioid alternatives could significantly enhance the patient experience and improve post-surgical recovery.

Dr.Camel's Conclusion

Just as the desert holds hidden treasures, this study reveals the potential of a novel ketorolac formulation to offer a safe and effective path for pain management. This research represents a step forward in the quest for alternative pain relief strategies, promising a future where postoperative pain is managed with greater precision and fewer unwanted side effects.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-09
Further Info :

Pubmed ID

38070041

DOI: Digital Object Identifier

10.1007/s12325-023-02709-5

Related Literature

Article Analysis
・Side Effects of ketorolac
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.