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Importance of internal controls, statistical methods, and side effects in short-term trials of vasodilators: a study of hydralazine kinetics in patients with aortic regurgitation.

Author: ChandraratnaP A, ElkayamU, KawanishiD T, McKayC R, NanaM, RahimtoolaS H, WeissJ N

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hydralazine increased cardiac output in patients with aortic regurgitation, but more frequent dosing led to higher rates of side effects.
Paper Details　
Original Abstract of the Article :
We determined that the spontaneous changes in cardiac output (CO) over 12 hr in 21 patients with chronic severe aortic regurgitation averaged +/- 8.9% (p = .03). We then measured changes in CO over time after administering incremental doses of oral hydralazine (50, 100, 150, and 200 mg) every 12 hr ...See full text at original site
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引用元：
https://doi.org/10.1161/01.cir.72.4.865

データ提供：米国国立医学図書館（NLM）

Hydralazine Kinetics: Understanding Its Effects on Heart Function

Aortic regurgitation, a heart condition, occurs when the heart valve doesn't close properly, allowing blood to leak back into the heart. It's like a leaky oasis well, where water continuously flows back into the well instead of nourishing the oasis. This study investigates the effects of hydralazine, a vasodilator medication, on heart function in patients with aortic regurgitation.

The researchers carefully analyzed the changes in cardiac output after administering hydralazine to patients with aortic regurgitation. They explored the impact of different doses and timing of administration, highlighting the importance of internal controls and appropriate statistical methods for accurate data analysis. Their findings provide valuable insights into the kinetics and effects of hydralazine in managing aortic regurgitation.

Hydralazine: A Complex Medication

This study provides a thorough analysis of hydralazine kinetics, highlighting the importance of careful dosing and monitoring to maximize its effectiveness and minimize potential side effects. It's like understanding the nuances of desert winds, knowing how to harness their power while mitigating their potential for damage.

Navigating Heart Health: A Desert Oasis of Knowledge

It's essential to consult with your healthcare provider to understand the potential benefits and risks of medications, including hydralazine, and to ensure they are used safely and effectively for your specific condition. It's like navigating a vast desert with a skilled guide, ensuring you reach your destination safely and successfully.

Dr.Camel's Conclusion

This study offers valuable insights into the kinetics and effects of hydralazine in managing aortic regurgitation. It emphasizes the importance of careful dose management, accurate data analysis, and understanding the complex interaction of medications with heart function.

Date :
  1. Date Completed 1985-10-24
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

3896565

DOI: Digital Object Identifier

10.1161/01.cir.72.4.865

Related Literature

Article Analysis
・Side Effects of hydralazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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