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Gastrointestinal cytoprotective effects of misoprostol. Clinical efficacy overview.

Author: DajaniE Z, NissenC H

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Misoprostol, a synthetic analog of prostaglandin E1, was found to have cytoprotective activity in humans. The drug significantly inhibited aspirin-induced gastric microbleeding and fecal blood loss. Misoprostol also reduced acid and chloride secretion and attenuated the drop in transmucosal potential difference induced by sodium taurocholate.
Paper Details　
Original Abstract of the Article :
The cytoprotective effects of misoprostol, a synthetic analog of prostaglandin E1, were investigated in healthy human subjects using randomized and placebo-controlled studies. Misoprostol significantly inhibited established aspirin (975 mg q.i.d.)-induced gastric microbleeding at 50 micrograms q.i.d...See full text at original site
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引用元：
https://doi.org/10.1007/BF01309408

データ提供：米国国立医学図書館（NLM）

Misoprostol: A Shield Against Gastrointestinal Damage

Misoprostol, a synthetic prostaglandin E1 analog, has been shown to have cytoprotective effects on the gastrointestinal tract. This study investigated the cytoprotective effects of misoprostol in healthy human subjects. The study found that misoprostol significantly inhibited aspirin-induced gastric microbleeding and reduced acid and chloride secretion. The study also found that misoprostol reduced fecal blood loss when administered concurrently with aspirin. These findings suggest that misoprostol has cytoprotective activity in humans and could be a valuable tool for preventing and treating gastrointestinal damage.

A Shield Against Gastrointestinal Damage

This study demonstrates the cytoprotective effects of misoprostol in humans. The study found that misoprostol can effectively reduce aspirin-induced gastric damage and fecal blood loss. This research provides valuable insights into the potential of misoprostol as a protective agent for the gastrointestinal tract.

A Safe Haven in the Desert of Digestive Distress

This research offers a glimmer of hope for individuals suffering from gastrointestinal distress. The study suggests that misoprostol can be a valuable tool for protecting the gastrointestinal tract from damage. It's like finding a hidden oasis in the vast desert of digestive distress.

Dr. Camel's Conclusion

This study shows that misoprostol has significant cytoprotective effects in humans. This research provides valuable insights into the potential of misoprostol as a treatment option for preventing and treating gastrointestinal damage.

Date :
  1. Date Completed 1985-12-06
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

3932054

DOI: Digital Object Identifier

10.1007/BF01309408

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Languages

English

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