A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules.

Author: BrownD D, HullJ H, LongR A, SchmidJ

Paper Details 
Original Abstract of the Article :
Drug interactions can profoundly alter the absorption of digoxin in tablet form. This study evaluated whether digoxin solution in capsules, a new dosage form with 90% to 100% bioavailability, would reduce such alterations, specifically those caused by cholestyramine and propantheline bromide. The in...See full text at original site
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引用元:
https://doi.org/10.1002/j.1552-4604.1985.tb02855.x

データ提供:米国国立医学図書館(NLM)

Navigating Digoxin Bioavailability: The Role of Propantheline Bromide and Cholestyramine

This study investigates the intricate world of [pharmacokinetics] and its implications for [drug interactions]. The focus is on digoxin, a medication commonly used for [heart conditions], and its absorption when administered in tablet or capsule form. The authors explore the potential influence of two drugs, propantheline bromide and cholestyramine, on the bioavailability of digoxin. They conducted a carefully designed study to determine if the new capsule formulation of digoxin could minimize the effects of these interactions.

Digoxin Bioavailability: A Balancing Act

The study reveals that the bioavailability of digoxin tablets is significantly affected by both propantheline bromide and cholestyramine. The authors found that digoxin capsules, offering higher bioavailability, demonstrate a reduced susceptibility to these interactions. Specifically, digoxin tablets exhibited a significant decrease in bioavailability when co-administered with cholestyramine. The researchers emphasize the importance of considering these interactions when prescribing digoxin to patients.

Mindful Medication: Considerations for Digoxin Use

This study highlights the importance of understanding drug interactions and their impact on medication efficacy. It emphasizes the need for healthcare professionals to carefully consider the potential interactions of digoxin with other medications, especially propantheline bromide and cholestyramine. The study suggests that the new capsule formulation of digoxin may offer a more reliable and consistent approach for managing these interactions. It's a reminder that medication management requires careful consideration of factors beyond the intended therapeutic effect.

Dr.Camel's Conclusion

Digoxin, a valuable tool in the treatment of heart conditions, presents a complex puzzle of drug interactions. This study, like a map guiding travelers through the desert, reveals the potential pitfalls of co-administering digoxin with certain medications. By highlighting the impact of propantheline bromide and cholestyramine on digoxin bioavailability, the study underscores the importance of careful medication management and the need to consider the nuances of drug interactions.

Date :
  1. Date Completed 1985-09-27
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

4031112

DOI: Digital Object Identifier

10.1002/j.1552-4604.1985.tb02855.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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