Effects of the newer nonsteroidal anti-inflammatory agents, ibuprofen, fenoprofen, and sulindac, on neutrophil adherence.

Author: DiVincenzoC, PearlmanF, PhairJ P, VenezioF R

Paper Details 
Original Abstract of the Article :
Administration of corticosteroids, aspirin, or indomethacin induces marked inhibition of adherence of polymorphonuclear leukocytes (PMNLs) in vitro. The effects of three newer nonsteroidal anti-inflammatory agents on PMNL adherence were defined. Adherence of PMNLs after passage through a nylon-wool ...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/152.4.690

データ提供:米国国立医学図書館(NLM)

Nonsteroidal Anti-inflammatory Drugs: Impact on Neutrophil Adherence

The research on [nonsteroidal anti-inflammatory drugs (NSAIDs)] continues to unravel their complex mechanisms of action and potential effects on various biological processes. This study explored the impact of three newer NSAIDs (ibuprofen, fenoprofen, and sulindac) on neutrophil adherence, a crucial aspect of the immune response.

NSAIDs and Neutrophil Adherence: A Complex Relationship

The researchers found that ibuprofen and fenoprofen significantly inhibited neutrophil adherence, while sulindac had a milder effect. These findings suggest that certain NSAIDs may modulate the immune response by affecting neutrophil function, potentially impacting inflammatory processes. The study further explored the mechanisms underlying this effect, suggesting a partially plasma-mediated factor involved in the inhibition of neutrophil adherence.

Navigating the Landscape of NSAIDs

Understanding the effects of NSAIDs on immune function is crucial for clinicians to consider when prescribing these medications. While NSAIDs are widely used for pain relief and inflammation, it's essential to be aware of their potential impact on immune processes. Just as a camel must navigate the intricate pathways of the desert, healthcare providers must navigate the complex effects of NSAIDs to ensure optimal patient care.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of NSAIDs on neutrophil adherence, highlighting the need for further research to understand the implications for immune function. The findings suggest that certain NSAIDs may modulate the immune response, adding another layer of complexity to their therapeutic effects. As a camel who has witnessed the resilience of desert life, I am fascinated by the delicate balance of the immune system and its intricate interactions with various medications.

Date :
  1. Date Completed 1985-11-04
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

4045229

DOI: Digital Object Identifier

10.1093/infdis/152.4.690

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