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Effects of the newer nonsteroidal anti-inflammatory agents, ibuprofen, fenoprofen, and sulindac, on neutrophil adherence.
Author: DiVincenzoC, PearlmanF, PhairJ P, VenezioF R
Original Abstract of the Article :
Administration of corticosteroids, aspirin, or indomethacin induces marked inhibition of adherence of polymorphonuclear leukocytes (PMNLs) in vitro. The effects of three newer nonsteroidal anti-inflammatory agents on PMNL adherence were defined. Adherence of PMNLs after passage through a nylon-wool ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1093/infdis/152.4.690
データ提供:米国国立医学図書館(NLM)
Nonsteroidal Anti-inflammatory Drugs: Impact on Neutrophil Adherence
The research on [nonsteroidal anti-inflammatory drugs (NSAIDs)] continues to unravel their complex mechanisms of action and potential effects on various biological processes. This study explored the impact of three newer NSAIDs (ibuprofen, fenoprofen, and sulindac) on neutrophil adherence, a crucial aspect of the immune response.
NSAIDs and Neutrophil Adherence: A Complex Relationship
The researchers found that ibuprofen and fenoprofen significantly inhibited neutrophil adherence, while sulindac had a milder effect. These findings suggest that certain NSAIDs may modulate the immune response by affecting neutrophil function, potentially impacting inflammatory processes. The study further explored the mechanisms underlying this effect, suggesting a partially plasma-mediated factor involved in the inhibition of neutrophil adherence.
Navigating the Landscape of NSAIDs
Understanding the effects of NSAIDs on immune function is crucial for clinicians to consider when prescribing these medications. While NSAIDs are widely used for pain relief and inflammation, it's essential to be aware of their potential impact on immune processes. Just as a camel must navigate the intricate pathways of the desert, healthcare providers must navigate the complex effects of NSAIDs to ensure optimal patient care.
Dr.Camel's Conclusion
This study provides valuable insights into the effects of NSAIDs on neutrophil adherence, highlighting the need for further research to understand the implications for immune function. The findings suggest that certain NSAIDs may modulate the immune response, adding another layer of complexity to their therapeutic effects. As a camel who has witnessed the resilience of desert life, I am fascinated by the delicate balance of the immune system and its intricate interactions with various medications.
Date :
- Date Completed 1985-11-04
- Date Revised 2019-05-11
Further Info :
Related Literature
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