Paper Details 
Original Abstract of the Article :
Theoretical models for percutaneous penetration are described, and a diffusion apparatus useful in the evaluation of transport kinetics of drugs applied to skin is discussed. Experimental data are presented for: (a) the flux of diflorasone diacetate through hairless mouse skin, (b) the percutaneous ...See full text at original site
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引用元:
https://doi.org/10.1002/jps.2600680306

データ提供:米国国立医学図書館(NLM)

Optimizing Drug Delivery: A Desert of Skin Penetration

In the field of dermatology, researchers are constantly seeking to improve the delivery of medications to the skin. This research delves into the complex world of percutaneous penetration, exploring how different vehicle components can influence the rate at which drugs are absorbed through the skin. The researchers investigated the effects of polyoxypropylene 15 stearyl ether and propylene glycol on the penetration rate of diflorasone diacetate, a topical corticosteroid.

Optimizing Penetration Rates: A Quest for the Best Path

The study revealed that the concentration of solvents in the vehicle can significantly affect the penetration rate of the drug. It’s as if we are navigating a desert landscape, where different paths lead to different destinations. The researchers found that optimizing the solvent concentration could enhance the penetration of diflorasone diacetate, ensuring that the drug reaches its target effectively. This research provides valuable insights for developing more effective topical formulations, helping to improve the delivery and efficacy of medications applied to the skin.

Understanding Drug Delivery: A Wise Traveler’s Perspective

This research highlights the importance of understanding the complex interplay between drug formulations and skin penetration. Just as a wise traveler in the desert chooses the best route based on the terrain and conditions, researchers must carefully consider the vehicle components and their impact on drug delivery. By understanding these factors, we can develop more effective topical formulations that deliver medications efficiently and safely.

Dr.Camel's Conclusion

This research reminds us that the desert of drug delivery is a complex and nuanced landscape. By understanding the factors that influence skin penetration, we can develop more effective topical formulations that deliver medications precisely where they are needed. It’s like choosing the right camel for a journey through the desert; the right vehicle can make all the difference in ensuring a smooth and successful journey.

Date :
  1. Date Completed 1979-05-23
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

423113

DOI: Digital Object Identifier

10.1002/jps.2600680306

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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