Correlation of subjective side effects with plasma concentrations of nortriptyline.

Author: AsbergM, CronholmB, SjöqvistF, TuckD

Paper Details 
Original Abstract of the Article :
Plasma levels of tricyclic antidepressant drugs vary considerably between individuals receiving the same amount of drug. The bearing of this variation on the occurrence of subjective side effects was investigated in 40 psychiatric inpatients with depressive disorders. Plasma levels were determined b...See full text at original site
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引用元:
https://doi.org/10.1136/bmj.4.5726.18

データ提供:米国国立医学図書館(NLM)

Nortriptyline: A Look at its Plasma Levels and Side Effects

The [pharmacology] of medications is a complex landscape, and understanding how drugs interact with the body is crucial for effective treatment. This study, like a careful explorer navigating a vast desert of chemical compounds, investigates the relationship between [nortriptyline] plasma levels and subjective side effects.

Plasma Levels and Side Effects: A Complex Relationship

The researchers discovered that plasma levels of nortriptyline varied considerably between patients, even when they received the same dosage. They also found that side effects were more pronounced at higher plasma levels. This is like a mirage in the desert, where appearances can be deceiving. The study highlights the importance of individualizing treatment approaches to optimize drug efficacy and minimize side effects.

Personalized Approaches to Medication Management

This study emphasizes the need to consider individual variations when administering medication. By monitoring plasma levels and adjusting dosage accordingly, we can optimize treatment effectiveness and minimize the risk of adverse effects. It's a reminder that the journey through the desert of pharmacology requires careful navigation and an understanding of individual needs.

Dr.Camel's Conclusion

This study provides valuable insights into the complexities of nortriptyline treatment. By understanding the relationship between plasma levels and side effects, we can personalize treatment approaches and ensure safer and more effective care for patients. It's a reminder that the journey through the desert of medicine requires careful attention to detail and a willingness to adapt to individual needs.

Date :
  1. Date Completed 1970-12-02
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

5470429

DOI: Digital Object Identifier

10.1136/bmj.4.5726.18

Related Literature

SNS
PICO Info
in preparation
Languages

English

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