Efficacy of mexiletine in the medium-term treatment of ventricular arrhythmias. A randomized, double-blind, crossover trial against placebo in ambulatory patients.

Author: CasoloG C, IeriA, MasottiG, MorettiniA, SerneriG G, ZipoliA

Paper Details 
Original Abstract of the Article :
A double-blind, crossover study was designed to compare the safety and efficacy of mexiletine with that of placebo in reducing premature ventricular complexes (PVC) in ambulatory patients and to find out the dose which gives a good therapeutic response with a minimal incidence of side-effects. Twent...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1177/030006058401200202

データ提供:米国国立医学図書館(NLM)

Mexiletine: A Potential Treatment for Ventricular Arrhythmias

Imagine a camel caravan traversing a vast desert, each camel's heartbeat a rhythmic pulse. Ventricular arrhythmias are like a disruption in this rhythm, causing erratic heartbeats and potential complications. This study investigates the effectiveness of mexiletine, a medication used to treat these arrhythmias, in a controlled trial setting. The researchers evaluated the drug's ability to reduce the frequency of premature ventricular complexes (PVCs) and determined the optimal dosage.

Mexiletine's Effectiveness in Reducing PVCs

The study found that mexiletine significantly reduced the frequency of PVCs in patients, demonstrating its effectiveness in treating ventricular arrhythmias. The researchers determined an effective dose of 600 mg per day, providing a valuable guideline for clinicians. This study provides encouraging evidence for the use of mexiletine in managing these heart rhythm disturbances.

Living with Ventricular Arrhythmias

Ventricular arrhythmias can be a source of anxiety and concern for patients. This study provides hope for those seeking effective treatment options. It emphasizes the importance of consulting with a healthcare professional to discuss the best course of action. Further research is needed to explore the long-term effects of mexiletine and to identify other potential treatment strategies for ventricular arrhythmias.

Dr.Camel's Conclusion

This study provides evidence for the effectiveness of mexiletine in managing ventricular arrhythmias. It underscores the importance of understanding the optimal dosage and recognizing potential side effects. This research contributes to the growing body of knowledge regarding the treatment of heart rhythm disorders.

Date :
  1. Date Completed 1984-07-02
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

6202571

DOI: Digital Object Identifier

10.1177/030006058401200202

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.