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Efficacy of mexiletine in the medium-term treatment of ventricular arrhythmias. A randomized, double-blind, crossover trial against placebo in ambulatory patients.
Author: CasoloG C, IeriA, MasottiG, MorettiniA, SerneriG G, ZipoliA
Original Abstract of the Article :
A double-blind, crossover study was designed to compare the safety and efficacy of mexiletine with that of placebo in reducing premature ventricular complexes (PVC) in ambulatory patients and to find out the dose which gives a good therapeutic response with a minimal incidence of side-effects. Twent...See full text at original site
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引用元:
https://doi.org/10.1177/030006058401200202
データ提供:米国国立医学図書館(NLM)
Mexiletine: A Potential Treatment for Ventricular Arrhythmias
Imagine a camel caravan traversing a vast desert, each camel's heartbeat a rhythmic pulse. Ventricular arrhythmias are like a disruption in this rhythm, causing erratic heartbeats and potential complications. This study investigates the effectiveness of mexiletine, a medication used to treat these arrhythmias, in a controlled trial setting. The researchers evaluated the drug's ability to reduce the frequency of premature ventricular complexes (PVCs) and determined the optimal dosage.
Mexiletine's Effectiveness in Reducing PVCs
The study found that mexiletine significantly reduced the frequency of PVCs in patients, demonstrating its effectiveness in treating ventricular arrhythmias. The researchers determined an effective dose of 600 mg per day, providing a valuable guideline for clinicians. This study provides encouraging evidence for the use of mexiletine in managing these heart rhythm disturbances.
Living with Ventricular Arrhythmias
Ventricular arrhythmias can be a source of anxiety and concern for patients. This study provides hope for those seeking effective treatment options. It emphasizes the importance of consulting with a healthcare professional to discuss the best course of action. Further research is needed to explore the long-term effects of mexiletine and to identify other potential treatment strategies for ventricular arrhythmias.
Dr.Camel's Conclusion
This study provides evidence for the effectiveness of mexiletine in managing ventricular arrhythmias. It underscores the importance of understanding the optimal dosage and recognizing potential side effects. This research contributes to the growing body of knowledge regarding the treatment of heart rhythm disorders.
Date :
- Date Completed 1984-07-02
- Date Revised 2017-02-14
Further Info :
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