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Effect of choline magnesium trisalicylate on prostacyclin production by isolated vascular tissue of the rat.

Author: LevyJ V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Choline magnesium trisalicylate (Trilisate) did not affect the production of prostacyclin-like substance by rat aortic tissue at therapeutic concentrations. Its ED50 for inhibition was 1200 mg/100 ml, which is 40 times higher than the maximum therapeutic blood concentration in humans. These results suggest that Trilisate does not adversely affect blood vessel function at therapeutic doses.
Paper Details　
Original Abstract of the Article :
Choline Magnesium Trisalicylate (Trilisate), in therapeutic concentrations of 5, 10, 15 and 30 mg/100 ml, did not significantly affect production of prostacyclin-like (PGI2) substance by rat aortic tissue in vitro. The ED50 for inhibition of aorta PGI2-like substance production by Trilisate was 1,20...See full text at original site
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引用元：
https://doi.org/10.1016/0049-3848(83)90136-6

データ提供：米国国立医学図書館（NLM）

Choline Magnesium Trisalicylate and Prostacyclin Production: A Balanced Approach to Inflammation

Inflammation, like a desert fire, can be a destructive force. This study examines the effects of choline magnesium trisalicylate (Trilisate), an anti-inflammatory medication, on prostacyclin production in blood vessels. Researchers are like skilled firefighters, carefully investigating the interactions between different compounds to find ways to extinguish the flames of inflammation.

Trilisate and Prostacyclin: A Balanced Dance in the Desert

This study found that Trilisate did not significantly affect prostacyclin production in rat aortic tissue at therapeutic concentrations. It's like a camel carefully navigating a desert oasis, ensuring that its actions don't disrupt the delicate balance of the ecosystem. The researchers also compared Trilisate to ibuprofen, finding that ibuprofen was much more potent in inhibiting prostacyclin production. This research highlights the importance of understanding the specific effects of different anti-inflammatory medications on blood vessel function.

Health Implications and Life Applications

This study suggests that Trilisate is a safe and effective anti-inflammatory medication that does not interfere with the important role of prostacyclin in maintaining blood vessel health. For individuals experiencing inflammation, discussing treatment options with their healthcare providers is crucial to find the right balance between managing symptoms and preserving overall health. It's like choosing the right tools for the job in the desert, ensuring a safe and healthy journey.

Dr.Camel's Conclusion

This research reminds us that even in the realm of inflammation, finding the right balance is key. Trilisate, with its minimal impact on prostacyclin production, offers a safe and effective approach to managing inflammation, much like a camel navigating the desert with a careful and balanced stride.

Date :
  1. Date Completed 1983-06-10
  2. Date Revised 2019-07-27
Further Info :

Pubmed ID

6342204

DOI: Digital Object Identifier

10.1016/0049-3848(83)90136-6

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Article Analysis
・Effects of choline magnesium trisalicylate
SNS
PICO Info
in preparation
Languages

English

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