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Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.

Author: GeyerG, ResnickR B, WashtonA M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lofexidine was effective in reducing opiate withdrawal symptoms without the sedative and hypotensive effects seen with clonidine.
Paper Details　
Original Abstract of the Article :
In an open clinical trial, lofexidine, an alpha-noradrenergic agonist similar to clonidine, was administered to 30 opiate-dependent outpatient volunteers following abrupt discontinuation of chronic methadone or levo-alpha acetylmethadol (LAAM). Lofexidine significantly reduced opiate withdrawal symp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6355070

データ提供：米国国立医学図書館（NLM）

Lofexidine: A Safer Alternative for Opiate Withdrawal

Opiate withdrawal can be a challenging and uncomfortable experience, often requiring medication to manage withdrawal symptoms. This study investigates the effectiveness and safety of [lofexidine], a [clonidine analogue], in managing opiate withdrawal symptoms. Researchers conducted an open clinical trial, administering lofexidine to patients undergoing opiate withdrawal. Their findings suggest that lofexidine effectively reduces withdrawal symptoms without the significant side effects associated with clonidine, offering a potentially safer and more effective treatment option for opiate withdrawal.

Lofexidine: A Promising Option for Opiate Withdrawal

This study presents [lofexidine] as a potentially safer and more effective alternative to clonidine for managing opiate withdrawal symptoms. The research found that lofexidine effectively reduced withdrawal symptoms while exhibiting fewer side effects, particularly those related to sedation and hypotension. These findings suggest that lofexidine could be a valuable tool for managing opiate withdrawal, especially for patients who are not suitable for clonidine therapy.

Understanding Opiate Withdrawal

Opiate withdrawal can be a difficult and uncomfortable experience. This study highlights the importance of safe and effective treatment options for managing withdrawal symptoms. If you are struggling with opiate withdrawal, it’s essential to seek professional help from qualified healthcare providers to ensure you receive the best possible care and support.

Dr. Camel's Conclusion

Just like the desert, which can be a place of harsh conditions but also offers sources of respite, opiate withdrawal can be a challenging journey, but effective treatment options are available. This study highlights the potential of lofexidine as a safer and more effective alternative to clonidine, offering hope for a more comfortable and successful recovery from opiate dependence.

Date :
  1. Date Completed 1983-12-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6355070

DOI: Digital Object Identifier

6355070

Related Literature

Article Analysis
・Side Effects of clonidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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