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[Pharmacological evaluation of an ampicillin suppository (KS-R1) in acute pneumonia in children--a comparison with a parenteral preparation of ampicillin].

Author: FujimotoT, IshimotoK, IwaiN, MizoguchiF, MotohiroT, NishiyamaT, SasakiA, TanedaY, TominagaK, YamashitaF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ampicillin rectal suppository was as effective as intravenous injection of ampicillin in treating acute bacterial pneumonia in children.
Paper Details　
Original Abstract of the Article :
A comparative well-controlled study was performed to evaluate the efficacy and tolerability of KS-R1 (ampicillin (ABPC) rectal suppository) compared with those of intravenous injection of ABPC against acute bacterial pneumonia caused by ABPC-sensitive bacteria, such as Streptococcus pyogenes, Strept...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6361319

データ提供：米国国立医学図書館（NLM）

A Comparative Study: Ampicillin Suppositories for Kids with Pneumonia

Pediatrics is a vast desert, and sometimes treating kids with pneumonia feels like navigating a sandstorm. This research is like a well-placed oasis, providing a much-needed alternative to intravenous ampicillin. This study focused on comparing the effectiveness of ampicillin suppositories (KS-R1) with intravenous ampicillin in treating children with pneumonia caused by sensitive bacteria.

The researchers used a controlled study design, similar to a caravan carefully following a set route, to ensure reliable results. They administered KS-R1 and intravenous ampicillin to 68 children aged 10 months to 8 years and 2 months. The results showed similar clinical efficacy rates between the two groups. However, KS-R1 demonstrated significant superiority in children aged 1 to 3 years.

KS-R1: A Viable Option for Pediatric Pneumonia

The study found that KS-R1, at a dosage of 250 mg four times a day, exhibited similar clinical efficacy and safety to intravenous ampicillin at a dosage of 125 mg four times a day. This suggests that KS-R1 could serve as a valuable alternative for treating acute bacterial pneumonia in children, especially for those aged 1 to 3 years. This is great news, like discovering a new water source in the desert.

A Smoother Journey for Little Ones

KS-R1 provides a less invasive treatment option for young patients, avoiding the need for intravenous injections. This means fewer needles and a potentially more comfortable experience for children, making the journey to recovery smoother and more pleasant.

Dr.Camel's Conclusion

This research provides a new path in the desert of pediatric pneumonia treatments. The study’s findings suggest that KS-R1 is a safe and effective treatment option, particularly for children between 1 and 3 years old. This valuable insight could lead to a more comfortable and potentially less traumatic experience for young patients.

Date :
  1. Date Completed 1984-02-14
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

6361319

DOI: Digital Object Identifier

6361319

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SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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