Mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH) as a second-line regimen in lung cancer.

Author: ChahinianA P, GreenG, HollandJ F

Paper Details 
Original Abstract of the Article :
Fifty-three patients with advanced lung cancer refractory to chemotherapy with MACC (methotrexate, adriamycin, cyclophosphamide, and CCNU) were treated with a combination of mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH). Among 45 evaluable patients, there were seven partial respon...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1097/00000421-198410000-00006

データ提供:米国国立医学図書館(NLM)

Exploring Second-Line Regimens for Lung Cancer

Lung cancer remains a significant health concern, often requiring multiple lines of treatment to combat its progression. This study investigated the effectiveness of a combination of mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH) as a second-line regimen for patients with advanced lung cancer who had not responded to initial chemotherapy. The researchers aimed to assess the efficacy of this combination therapy and its potential to overcome drug resistance.

MEPH: A Potential Second-Line Option for Lung Cancer

The study found a modest response rate to MEPH, with seven out of 45 evaluable patients experiencing partial remission. Although the response rate was relatively low, the researchers observed a lack of cross-resistance between MEPH and the initial chemotherapy regimen, suggesting that MEPH may be a viable option for patients who have not responded to other treatments.

Navigating the Challenges of Lung Cancer Treatment

This research, like a desert oasis providing respite for weary travelers, offers a potential treatment option for patients battling lung cancer. However, further research is essential to optimize the use of MEPH and explore other promising second-line therapies.

Dr.Camel's Conclusion

This study, much like a seasoned traveler navigating a vast desert, explores the complex landscape of lung cancer treatment. The researchers, driven by their pursuit of effective therapies, have identified a potential second-line regimen that could provide hope for patients who have exhausted other treatment options. As our knowledge of cancer continues to grow, we can expect even more effective and targeted therapies to emerge, offering brighter prospects for patients and their families.

Date :
  1. Date Completed 1984-12-31
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6439029

DOI: Digital Object Identifier

10.1097/00000421-198410000-00006

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.