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Mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH) as a second-line regimen in lung cancer.
Author: ChahinianA P, GreenG, HollandJ F
Original Abstract of the Article :
Fifty-three patients with advanced lung cancer refractory to chemotherapy with MACC (methotrexate, adriamycin, cyclophosphamide, and CCNU) were treated with a combination of mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH). Among 45 evaluable patients, there were seven partial respon...See full text at original site
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引用元:
https://doi.org/10.1097/00000421-198410000-00006
データ提供:米国国立医学図書館(NLM)
Exploring Second-Line Regimens for Lung Cancer
Lung cancer remains a significant health concern, often requiring multiple lines of treatment to combat its progression. This study investigated the effectiveness of a combination of mitomycin-C, etoposide, cisplatin, and hexamethylmelamine (MEPH) as a second-line regimen for patients with advanced lung cancer who had not responded to initial chemotherapy. The researchers aimed to assess the efficacy of this combination therapy and its potential to overcome drug resistance.
MEPH: A Potential Second-Line Option for Lung Cancer
The study found a modest response rate to MEPH, with seven out of 45 evaluable patients experiencing partial remission. Although the response rate was relatively low, the researchers observed a lack of cross-resistance between MEPH and the initial chemotherapy regimen, suggesting that MEPH may be a viable option for patients who have not responded to other treatments.
Navigating the Challenges of Lung Cancer Treatment
This research, like a desert oasis providing respite for weary travelers, offers a potential treatment option for patients battling lung cancer. However, further research is essential to optimize the use of MEPH and explore other promising second-line therapies.
Dr.Camel's Conclusion
This study, much like a seasoned traveler navigating a vast desert, explores the complex landscape of lung cancer treatment. The researchers, driven by their pursuit of effective therapies, have identified a potential second-line regimen that could provide hope for patients who have exhausted other treatment options. As our knowledge of cancer continues to grow, we can expect even more effective and targeted therapies to emerge, offering brighter prospects for patients and their families.
Date :
- Date Completed 1984-12-31
- Date Revised 2019-09-04
Further Info :
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English
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