Favorable effects of glibenclamide in a patient exhibiting idiosyncratic hepatotoxic reactions to both chlorpropamide and tolbutamide.

Author: BotaB, RumboldtZ

Paper Details 
Original Abstract of the Article :
A middle-aged diabetic woman after four weeks of chlorpropamide treatment developed cholestatic hepatitis with systemic manifestations of idiosyncratic reaction. After recovery, unintended rechallenge with the same drug induced a brisk exacerbation of the symptoms and signs that reversed completely ...See full text at original site
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引用元:
https://doi.org/10.1007/BF02582093

データ提供:米国国立医学図書館(NLM)

Glibenclamide: A Beacon of Hope in a Desert of Drug Reactions

The world of medication can sometimes feel like a vast desert, with unexpected side effects lurking around every corner. This case study presents a fascinating journey through the challenges of drug reactions, showcasing the effectiveness of glibenclamide (glyburide) in a patient who experienced severe idiosyncratic reactions to both chlorpropamide and tolbutamide. The study highlights the importance of individual patient responses to medication and underscores the need for careful monitoring and alternative treatments when necessary.

The Importance of Individualized Therapy

This case study exemplifies the individualistic nature of drug responses. What works for one person may not work for another. It emphasizes the need for close observation and adjustment of treatment plans based on individual patient responses.

Navigating the Desert of Drug Reactions: A Collaborative Journey

This study emphasizes the collaborative nature of healthcare. When a patient experiences unexpected reactions, healthcare providers must work together to find the best course of action. The success of glibenclamide in this case demonstrates the importance of open communication and creative solutions in the face of adversity.

Dr.Camel's Conclusion

This study reminds us that we must approach medication with a cautious optimism. The desert of drug reactions can be daunting, but with careful monitoring and a collaborative spirit, we can navigate this challenging terrain and find the oasis of effective treatment for each individual patient.

Date :
  1. Date Completed 1985-04-11
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

6442088

DOI: Digital Object Identifier

10.1007/BF02582093

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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