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Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes.

Author: BregmanD J, KaterN A, KendalA P, PatriarcaP A, SikesR K, SmithJ D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Rimantadine hydrochloride (RH) was found to be safe for prophylaxis against influenza A in elderly nursing home residents. While transient nausea and anxiety were associated with RH administration, other side effects were rare and considered clinically insignificant. Serum RH levels were higher in elderly individuals compared to younger individuals, suggesting that lower dosages may be indicated for the elderly.
Paper Details　
Original Abstract of the Article :
We evaluated the safety of rimantadine hydrochloride (RH) prophylaxis in a double-blind, placebo-controlled trial in three nursing homes during a community epidemic of influenza A (H3N2). Although daily monitoring of the 35 participants revealed an association between RH administration (100 mg twice...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.26.1.101

データ提供：米国国立医学図書館（NLM）

Rimantadine Hydrochloride: A Safeguard Against Influenza in Nursing Homes

This study investigates the safety and efficacy of rimantadine hydrochloride (RH) in preventing influenza A virus infections in nursing homes. The researchers conducted a double-blind, placebo-controlled trial, monitoring 35 participants for potential side effects. While some transient side effects, like nausea and anxiety, were observed, they were considered clinically insignificant. The study also revealed that higher doses of RH may be needed in the elderly, suggesting the need for dosage adjustments based on age.

Rimantadine Hydrochloride: Effective Prophylaxis for the Elderly

This study provides valuable insights into the use of rimantadine hydrochloride for influenza prevention in elderly populations. The researchers found that RH effectively prevented influenza A infections while exhibiting a safe side-effect profile. The study's findings underscore the importance of considering age-related factors when determining optimal dosages for medications.

Protecting Vulnerable Populations: A Priority in Healthcare

This study underscores the importance of protecting vulnerable populations, such as those residing in nursing homes, from infectious diseases. The study's findings demonstrate the potential of prophylactic medications in preventing influenza outbreaks and safeguarding the health of elderly individuals. This research emphasizes the critical role of public health initiatives in protecting the most vulnerable members of our society.

Dr. Camel's Conclusion

This study demonstrates the importance of scientific rigor in evaluating the safety and efficacy of medications, especially in vulnerable populations. The findings underscore the need for tailored approaches to drug administration, considering individual factors like age. This research provides valuable knowledge for healthcare professionals in their efforts to protect the elderly and promote their well-being.
Date :
  1. Date Completed 1984-10-10
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

6476812

DOI: Digital Object Identifier

10.1128/AAC.26.1.101

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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