Disseminated intravascular coagulation induced by progesterone in the pregnant rat. Prevention by estogens.

Author: StamlerF W

Paper Details 
Original Abstract of the Article :
Fatal disseminated intravascular coagulation (DIC) was induced in female rats by administration of progesterone in late pregnacy. This prevented parturition, with intrauterine fetal death 2 to 4 days past term and subsequent retention of dead fetuses. Concomitantly with or closely following the intr...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032110/

データ提供:米国国立医学図書館(NLM)

Disseminated Intravascular Coagulation (DIC) Induced by Progesterone in Pregnant Rats

In the vast desert of scientific research, we often encounter mysteries that require our persistent exploration. This study, delving into the intricacies of [研究分野: pregnancy complications], focuses on the perilous effects of progesterone on pregnant rats. The researchers employed a meticulous approach, [研究手法: administering progesterone to pregnant rats], to unravel the underlying mechanisms of DIC. They discovered that progesterone, akin to a treacherous mirage in the desert, can lead to a life-threatening condition in pregnant rats, characterized by abnormal blood clotting and widespread damage to blood vessels, eventually leading to fetal demise and maternal death. This study sheds light on the complex interplay of hormones during pregnancy and its potential impact on maternal and fetal health.

The Power of Estrogen: A Beacon in the Storm

The researchers stumbled upon a crucial finding, akin to an oasis in the desert. They discovered that [研究結果: administering estrogen alongside progesterone] effectively prevented the development of DIC. This revelation highlights the vital role of estrogen in maintaining a delicate balance during pregnancy. This finding could have significant implications for the development of new treatments to prevent or manage DIC in humans.

Navigating the Sands of Pregnancy: A Guide for Expectant Mothers

While this study was conducted on rats, its implications are far-reaching. The results suggest that [健康的なベネフィット: maintaining a healthy estrogen balance during pregnancy] might be crucial for preventing DIC. It is important for expectant mothers to consult with their healthcare providers to ensure they receive proper prenatal care and address any potential hormonal imbalances.

Dr. Camel's Conclusion

This study, like a shimmering mirage, reveals the potential dangers of hormonal imbalances during pregnancy. The researchers' discovery that estrogen can counteract the deleterious effects of progesterone offers a glimmer of hope for mitigating DIC. Further research is needed to translate these findings into effective treatments for humans, ensuring a smoother journey through the desert of pregnancy.

Date :
  1. Date Completed 1977-04-25
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

65916

DOI: Digital Object Identifier

PMC2032110

Related Literature

SNS
PICO Info
in preparation
Languages

English

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