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Effects of molindone and fluphenazine on the brain concentration of some phenolic and catecholic amines in the mouse and the rat.

Author: JuorioA V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Molindone acted as a blocker or partial agonist of dopamine receptors, affecting tyramine levels and dopamine metabolism.
Paper Details　
Original Abstract of the Article :
1 The concentrations of p- and m-tyramine, dopamine, 3,4-dihydroxyphenylacetic acid and homo-vanillic acid were measured in the mouse or rat striatum following the subcutaneous injection of molindone or fluphenazine. The mouse hypothalamic levels of the m- or p-isomers of octopamine were also analys...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1476-5381.1980.tb08726.x

データ提供：米国国立医学図書館（NLM）

Effects of Molindone and Fluphenazine on the Brain Concentration of Some Phenolic and Catecholic Amines in the Mouse and the Rat

This research explores the intricate workings of the brain and how certain medications affect the delicate balance of neurochemicals. The researchers investigated the effects of molindone and fluphenazine, two antipsychotic drugs, on the levels of various neurotransmitters in the brains of mice and rats. Their findings offer insights into the mechanisms by which these drugs exert their effects.

Neurotransmitter Modulation and Antipsychotic Drugs

This study reveals that molindone and fluphenazine, both antipsychotic medications, have a significant impact on the levels of specific neurotransmitters in the brain. These findings contribute to our understanding of how these medications work at the molecular level and may offer valuable insights for developing more effective and targeted treatments for mental health conditions.

Understanding the Brain's Complex Chemistry

This study emphasizes the intricate interplay of neurochemicals within the brain. It reminds us that even subtle changes in these chemical messengers can have profound effects on our thoughts, emotions, and behaviors. Further research into the brain's complex chemistry is crucial for advancing our understanding of mental health and developing more effective treatment options.

Dr.Camel's Conclusion

Imagine a desert oasis, where a variety of plants and animals thrive. This research is like exploring the hidden pathways and secret oases of the brain, uncovering the intricate balance of neurochemicals that govern our thoughts and emotions.

Date :
  1. Date Completed 1981-02-24
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

6777007

DOI: Digital Object Identifier

10.1111/j.1476-5381.1980.tb08726.x

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Article Analysis
・Effects of molindone
SNS
PICO Info
in preparation
Languages

English

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