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Phase I trial of pentamethylmelamine in patients with previously treated malignancies.
Author: AisnerJ, ChiutenD F, LichtenfeldJ L, Van EchoD A, WhitacreM, WiernikP H
Original Abstract of the Article :
Pentamethylmelamine (PMM), a demethylated soluble analog of hexamethylmelamine, was given to 35 patients with solid tumors in a phase I clinical trial. Thirty patients were given single doses ranging from 80 to 2000 mg/m2 in a 2-hour infusion every 3 weeks. Once a maximum tolerated dose was defined ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://pubmed.ncbi.nlm.nih.gov/6781747
データ提供：米国国立医学図書館（NLM）
Pentamethylmelamine: A New Oasis in the Desert of Cancer Treatment
The fight against cancer is a relentless battle, like navigating a vast and unforgiving desert. This study, like a pioneering expedition searching for new treatments, investigates the safety and efficacy of pentamethylmelamine (PMM) in patients with previously treated malignancies. This research, like a diligent explorer mapping a new terrain, carefully examines the drug's side effects and its potential to combat cancer.
Pentamethylmelamine: A Potential Weapon Against Cancer
The researchers, like skilled desert navigators, carefully determined the maximum tolerated dose of PMM, finding that the drug was associated with central nervous system and gastrointestinal side effects. However, they also observed minor tumor regressions in two patients, suggesting that PMM, like a desert oasis offering respite, may hold promise as a treatment for certain cancers. These findings, like a beacon of hope in the distance, encourage further research to explore the potential of PMM as a cancer therapy.
Navigating the Desert of Side Effects
This study, like a wise traveler navigating a treacherous desert, acknowledges the challenges of managing PMM-related side effects. The researchers emphasize the importance of careful monitoring and dose adjustment to minimize adverse events. This study, like a roadmap guiding future research, provides valuable insights into the safety and efficacy of PMM and encourages further investigation to refine its use and explore its potential for treating various cancers.
Dr.Camel's Conclusion
This study offers a preliminary investigation into the safety and efficacy of pentamethylmelamine (PMM) in treating previously treated malignancies. The findings suggest that PMM holds potential as a cancer therapy, but emphasize the need for careful monitoring and dose adjustment to manage side effects. Further research is warranted to explore the efficacy and optimize the use of PMM in treating specific types of cancer.
Date :
- Date Completed 1981-05-28
- Date Revised 2017-11-17
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English
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