Phase I--II evaluation of combination cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in advanced breast cancer.

Author: ChangY C, CrowleyJ, FalksonG, TormeyD C

Paper Details 
Original Abstract of the Article :
A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer. Objective response was documented in 7 of 18 evaluable patients. The median duration of response was 99 days. Response was ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/6797746

データ提供:米国国立医学図書館(NLM)

Evaluating a Four-Drug Combination for Advanced Breast Cancer

Breast cancer is a complex and challenging disease, and finding effective treatment strategies is paramount. This research investigates the efficacy of a four-drug combination therapy for advanced breast cancer. The study explores the use of cyclophosphamide, 5-fluorouracil, hexamethylmelamine, and prednisone in a regimen designed to combat the disease's progression. The authors evaluate the drug combination's effectiveness and safety, analyzing its impact on objective response, duration of response, and potential side effects.

Promising Results for Advanced Breast Cancer Treatment

The research reveals encouraging results, demonstrating objective response in a significant portion of the study participants. The median duration of response was 99 days, suggesting the potential for long-term benefit. The study emphasizes the importance of tailoring treatment strategies to individual patients, as the response was observed more frequently in patients without visceral disease. The authors highlight the potential of this four-drug combination as an alternative treatment option for patients who have not responded to other chemotherapy regimens.

The Importance of Personalized Treatment

This study highlights the importance of personalized medicine, emphasizing the need to consider individual patient factors when designing treatment strategies. The researchers observed different response rates based on the presence or absence of visceral disease, underscoring the importance of tailoring treatment approaches to each patient's unique circumstances. This research provides valuable insights into the potential of a four-drug combination therapy for advanced breast cancer, offering a potential alternative for patients with limited treatment options. It's like discovering a new path through a vast desert, offering hope and potential solutions for those facing a challenging journey.

Dr. Camel's Conclusion

This research offers a glimmer of hope for patients with advanced breast cancer, presenting a potentially effective treatment strategy. The study underscores the importance of personalized medicine and the ongoing search for innovative treatments to combat this complex disease. It's like searching for a hidden oasis in a vast desert, offering hope and relief for those facing a challenging journey.

Date :
  1. Date Completed 1982-03-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6797746

DOI: Digital Object Identifier

6797746

Related Literature

SNS
PICO Info
in preparation
Languages

English

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