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Side-effects due to the intravenous infusion of erythromycin lactobionate.

Author: BlaserJ, LüthyR, PutziR, SiegenthalerW, WehrliR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Intravenous erythromycin lactobionate infusions were associated with a high incidence of systemic side effects, including abdominal cramps, nausea, vomiting, dizziness, and profuse sweating. The study was terminated early.
Paper Details　
Original Abstract of the Article :
A double-blind study was designed to test the hypothesis that local side-effects during i. v. administration of erythromycin lactobionate depend on the drug concentration and that they can therefore be minimized by dissolving erythromycin in a larger infusion volume. Forty healthy students were assi...See full text at original site
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引用元：
https://doi.org/10.1007/BF01641296

データ提供：米国国立医学図書館（NLM）

Erythromycin Lactobionate: A Journey Through the Desert of Side Effects

The desert of drug development can be treacherous, filled with unexpected side effects. This research, published in the field of pharmacology, investigates the side effects associated with intravenous erythromycin lactobionate. The authors conducted a double-blind study to assess the impact of drug concentration and infusion volume on side effect severity. The results revealed a high incidence of systemic side effects, including abdominal cramps, nausea, vomiting, dizziness, and profuse sweating, during the first 79 infusions. The study was terminated due to the severity of these side effects.

Navigating the Desert of Side Effects

This research highlights the importance of understanding the potential side effects of medications, especially when administered intravenously. The findings emphasize the need for careful monitoring and dose adjustments to minimize the risk of adverse events. It’s like navigating a desert, being aware of potential dangers and taking precautions to avoid them.

A Cautionary Tale in the Desert

This research serves as a cautionary tale in the desert of drug development. The authors demonstrate the importance of thorough testing and careful consideration of dosage and administration methods to minimize the risk of adverse effects. It’s like learning from the experiences of others who have traversed the desert before you, avoiding potential pitfalls and ensuring a safer journey.

Dr. Camel's Conclusion

This research underscores the importance of understanding the potential side effects of medications. The findings highlight the need for careful monitoring and dose adjustments to ensure the safety and well-being of patients. This research is like a signpost in the desert, reminding us to be vigilant and proceed with caution when navigating the complexities of drug therapy.

Date :
  1. Date Completed 1983-10-08
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

6885176

DOI: Digital Object Identifier

10.1007/BF01641296

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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