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The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels.

Author: AmsterdamJ, BrunswickD, MendelsJ

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tricyclic antidepressants are effective in treating depression. There is a suggested therapeutic range for some tricyclic antidepressants, however, more research is needed to determine the necessary plasma levels for others.
Paper Details　
Original Abstract of the Article :
The authors present a clinical approach for predicting and using plasma concentrations of tricyclic antidepressants in the treatment of depressed patients. They review the pharmacokinetics of this group of drugs and their side effects and toxicity. There is a suggested therapeutic range for plasma c...See full text at original site
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引用元：
https://doi.org/10.1176/ajp.137.6.653

データ提供：米国国立医学図書館（NLM）

Navigating the Sands of Tricyclic Antidepressant Therapy: A Guide to Dosage and Monitoring

Depression is a complex and debilitating illness, and finding the right medication and dosage can be a challenging journey. This study provides a clinical approach for predicting and using plasma concentrations of tricyclic antidepressants in the treatment of depressed patients.

The authors review the pharmacokinetics of tricyclic antidepressants, their side effects, and their toxicity. They emphasize the importance of monitoring plasma levels to optimize treatment and minimize adverse effects. The study also suggests a therapeutic range for specific tricyclic antidepressants, but acknowledges the need for further research to refine these guidelines.

Optimizing Tricyclic Antidepressant Therapy: A Quest for Balance

This study provides valuable insights into the use of tricyclic antidepressants, highlighting the importance of monitoring plasma levels to ensure effective treatment while minimizing potential risks. By carefully navigating the complex landscape of tricyclic antidepressant therapy, clinicians can help patients find relief from depression while ensuring their safety and well-being.

The Art of Dosage Adjustment: A Journey Towards Wellness

Just as a skilled camel handler guides their caravan across the desert, adjusting its pace and course to suit the terrain, clinicians must carefully adjust the dosage of tricyclic antidepressants to optimize treatment and minimize side effects, leading patients on a path towards recovery.

Dr.Camel's Conclusion

Depression, like a relentless desert heat, can be a challenging opponent. This study provides valuable guidance for clinicians, helping them to navigate the complex landscape of tricyclic antidepressant therapy, ensuring that patients receive the right dosage and care to overcome the challenges of depression. By carefully monitoring plasma levels and adjusting dosages, we can help patients find a path to healing and well-being.

Date :
  1. Date Completed 1980-07-28
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

6990798

DOI: Digital Object Identifier

10.1176/ajp.137.6.653

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Languages

English

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