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Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.

Author: HarleyE J, KellnerA, MorrisonJ M, OleszkoW R, SadovskyR, StevensC E, SzmunessW, WilliamD C, ZangE A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

An inactivated hepatitis B vaccine is effective in preventing hepatitis B infection in high-risk homosexual men. The vaccine is safe and has few side effects.
Paper Details　
Original Abstract of the Article :
We assessed the efficacy of an inactivated hepatitis B vaccine in a placebo-controlled, randomized, double-blind trial in 1083 homosexual men known to be at high risk for hepatitis B virus infection. The vaccine was found to be safe and the incidence of side effects was low. Within two months, 77% o...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM198010093031501

データ提供：米国国立医学図書館（NLM）

Hepatitis B Vaccine: Efficacy in a High-Risk Population

In the realm of [immunology] and [infectious diseases], researchers constantly seek ways to protect individuals from the threat of infectious diseases. This study examines the efficacy of an inactivated hepatitis B vaccine in a high-risk population, specifically homosexual men. The researchers conducted a placebo-controlled, randomized, double-blind trial, demonstrating the vaccine's safety and effectiveness in preventing hepatitis B infection. Their findings provide a powerful tool for combating this serious disease, like finding a hidden spring of protection in the desert of viral infections.

The Effectiveness of Hepatitis B Vaccination

The study demonstrates the significant effectiveness of the hepatitis B vaccine in preventing infection in a high-risk population. Within two months, a high percentage of vaccinated individuals developed high levels of antibodies against the hepatitis B surface antigen, indicating a strong immune response. This is akin to building a sturdy wall of immunity against the threat of infection, like a protective barrier against the harsh elements of the desert.

Protecting Individuals and Communities from Hepatitis B

The findings of this study underscore the importance of vaccination as a critical tool for preventing hepatitis B infection. By increasing vaccination rates, we can protect individuals and communities from the devastating consequences of this disease. Think of vaccination as a lifeline in the desert of infectious diseases – a vital resource that can protect us from harm.

Dr.Camel's Conclusion

The study highlights the crucial role of vaccination in preventing hepatitis B infection, particularly in high-risk populations. The findings demonstrate the vaccine's safety, effectiveness, and potential to significantly reduce the incidence of this disease. This research is a testament to the power of vaccination, offering hope in the vast desert of infectious diseases and providing a vital tool for protecting individuals and communities worldwide.
Date :
  1. Date Completed 1980-11-24
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

6997738

DOI: Digital Object Identifier

10.1056/NEJM198010093031501

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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