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Relationship between plasma-levels of chlorpromazine and effects on EEG and evoked potentials in healthy volunteers.

Author: BaumannP, GaillardJ M, LaurianS, LeP K, PereyM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Chlorpromazine had varying effects on brain electrical activity depending on individual sensitivity and dose.
Paper Details　
Original Abstract of the Article :
The effect of chlorpromazine (CPZ) was studied at four different doses in a group of 10 normal subjects. Blood levels of CPZ were assayed by gas chromatography and showed wide interindividual variations. Spontaneous brain electrical activity (EEG) was recorded from 8 leads and submitted to spectral ...See full text at original site
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引用元：
https://doi.org/10.1055/s-2007-1019598

データ提供：米国国立医学図書館（NLM）

Decoding the Brain's Response to Chlorpromazine

This study delves into the intricate workings of the [brain] and examines the effects of chlorpromazine (CPZ), an antipsychotic medication, on brain electrical activity (EEG) and evoked potentials in healthy volunteers. It's like navigating a labyrinthine desert, seeking to understand the complex pathways of the brain's response to medication. The researchers administered various doses of CPZ and meticulously measured the resulting EEG and evoked potential responses, identifying significant differences in brain activity between individuals who experienced side effects and those who didn't. They found that CPZ significantly altered EEG parameters and evoked potential measurements, depending on the dose and individual sensitivity.

Understanding Individual Differences

This study emphasizes the importance of considering individual differences in response to medications. It's like recognizing that each sand dune in the desert has its own unique shape and texture. The research team's thorough analysis reveals that CPZ has a wide range of effects on the brain, highlighting the need for personalized medicine approaches.

Navigating the Landscape of Medication

It's crucial to consult with a healthcare professional before taking any medications, including antipsychotics. They can help you understand the potential benefits and risks and ensure that the medication is appropriate for your individual needs.

Dr.Camel's Conclusion

This study is like a map guiding us through the intricate landscape of the brain. The researchers have successfully mapped the effects of CPZ on the brain, highlighting the importance of individual variations in drug response. This study underscores the need for personalized medicine approaches, taking into account the unique characteristics of each individual. As a wise camel, I encourage everyone to consult with their healthcare provider to make informed decisions about their medication and ensure their safety and well-being.
Date :
  1. Date Completed 1982-03-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7323140

DOI: Digital Object Identifier

10.1055/s-2007-1019598

SNS
PICO Info
in preparation
Languages

English

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