Treatment of chronic lymphocytic leukemia in early and stable phase of the disease: long-term results of a randomized trial.

Author: BrugiatelliM, CalleaV, IacopinoP, JaksicB, KusecR, LutzD, MorabitoF, OstojicS, Planinc-PeraicaA, StelitanoC

Paper Details 
Original Abstract of the Article :
In 1982 the IGCI CLL cooperative group decided to investigate the usefulness of treating, at diagnosis B-cell chronic lymphocytic leukemia (CLL) in early and stable phase of the disease. From January 1982 to December 1986, 148 patients were randomized either to receive immediate treatment with chlor...See full text at original site
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引用元:
https://doi.org/10.1111/j.1600-0609.1995.tb00244.x

データ提供:米国国立医学図書館(NLM)

Treating Chronic Lymphocytic Leukemia: A Tale of Two Approaches

Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. This research explores the optimal timing for treatment of CLL in patients with early and stable phases of the disease. The researchers conducted a randomized trial comparing immediate treatment with chlorambucil (CLB) to deferring therapy until disease progression. The study aimed to determine the impact of these two approaches on survival rates and other clinical outcomes.

Early Treatment Doesn’t Necessarily Lead to Longer Survival

The study found that there was no significant difference in overall survival between the two groups. This suggests that immediate chemotherapy with CLB does not improve survival in patients with early and stable phase CLL. While early treatment was associated with a better initial response and a slower progression rate, it did not translate to a significant survival advantage in the long run.

Navigating CLL Treatment Decisions

This study highlights the importance of carefully considering the individual characteristics of each patient when making treatment decisions. It’s like choosing the best path across a vast desert landscape – considering all factors, such as the terrain, resources, and weather, is crucial for a successful journey.

Dr.Camel's Conclusion

This study suggests that immediate chemotherapy may not be necessary for all patients with early and stable phase CLL. It’s like choosing a camel for a long journey – some journeys require a quick, strong camel, while others benefit from a more patient and cautious approach.

Date :
  1. Date Completed 1995-10-19
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

7672088

DOI: Digital Object Identifier

10.1111/j.1600-0609.1995.tb00244.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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