Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators.

Author: FeaganB G, FedorakR N, GilliesR, GreenbergG R, HopkinsM, IrvineE J, RochonJ, SteinhartA H, SutherlandL, WildG

Paper Details 
Original Abstract of the Article :
BACKGROUND: Although corticosteroids are highly effective in improving symptoms of Crohn's disease, they may have substantial toxicity. In some patients, attempts to discontinue corticosteroids are unsuccessful. METHODS: We conducted a double-blind, placebo-controlled multicenter study of weekly in...See full text at original site
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引用元:
https://doi.org/10.1056/NEJM199502023320503

データ提供:米国国立医学図書館(NLM)

Methotrexate: A Treatment Option for Crohn's Disease

Crohn's disease is a chronic inflammatory bowel disease that can be difficult to manage. Corticosteroids are effective in controlling symptoms, but long-term use can lead to serious side effects. This study investigates the efficacy of methotrexate, a drug typically used to treat cancer, in treating Crohn's disease patients who are not responding to corticosteroids. It's like a group of researchers exploring the use of a different type of fertilizer to sustain a fragile ecosystem in the desert.

Methotrexate: A Promising Alternative for Crohn's Disease

The study found that methotrexate was more effective than placebo in reducing Crohn's disease symptoms and decreasing the need for corticosteroids. It's like finding a new type of fertilizer that not only sustains the ecosystem but also promotes healthy growth. This study suggests that methotrexate may be a valuable alternative for Crohn's disease patients who are not responding to other treatments.

Navigating the Desert of Crohn's Disease

Crohn's disease can be a debilitating condition, and this study offers a potential new path for managing symptoms. It's like finding a new route through a challenging desert landscape, offering a way to avoid the harsh conditions of other treatments. This study encourages further research into the use of methotrexate for Crohn's disease, but also highlights the importance of monitoring potential side effects.

Dr. Camel's Conclusion

This study shines a light on the potential of methotrexate in treating Crohn's disease. It's like finding a hidden oasis in the desert of Crohn's disease, offering a potential source of relief and improved quality of life. This research encourages further exploration of methotrexate's role in managing Crohn's disease and emphasizes the need for continued research into new and effective treatment options.

Date :
  1. Date Completed 1995-02-03
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

7816064

DOI: Digital Object Identifier

10.1056/NEJM199502023320503

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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