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[Comparison of the protective effects of roxatidine and misoprostol on diclofenac gastroduodenal pathology. An endoscopic, controlled study of volunteers].

Author: JackischP, MüllerP, SimonB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The study compared the effectiveness of acid-lowering and mucosa-protective drugs in preventing gastroduodenal lesions caused by non-steroidal anti-inflammatory drugs (NSAIDs). Roxatidine, an acid-lowering drug, significantly reduced lesions compared to placebo, while misoprostol, a mucosa-protective drug, showed similar effectiveness to roxatidine. These findings suggest that both drug types can be used for prophylaxis and highlight the complex mechanisms by which NSAIDs damage the gastrointestinal tract.
Paper Details　
Original Abstract of the Article :
For prophylaxis of gastroduodenal lesions induced by non-steroidal antirheumatic drugs (NSAID) acid-lowering as well as mucosa protective substances are used. Direct comparison of both therapeutic regimens are lacking. In randomized parallel studies the gastroduodenal tolerability of 100 mg diclofen...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7818585

データ提供：米国国立医学図書館（NLM）

Protecting the Stomach: A Comparative Look at Gastroduodenal Protection

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to manage pain and inflammation, but they can also cause damage to the stomach and intestines. This study compares the protective effects of two medications, roxatidine and misoprostol, in preventing gastroduodenal lesions induced by diclofenac, a common NSAID.

Comparing Protective Strategies

The researchers conducted two randomized studies, comparing the effects of roxatidine and misoprostol on gastroduodenal damage induced by diclofenac. They found that roxatidine, a histamine H2 receptor antagonist, was more effective than placebo in protecting the stomach from damage. However, there was no significant difference in protective effects between roxatidine and misoprostol, a prostaglandin analog.

Balancing Pain Relief and Stomach Protection

The research highlights the importance of considering gastroduodenal protection when prescribing NSAIDs. It emphasizes the need to weigh the potential benefits of pain relief against the risk of stomach damage and to choose appropriate protective strategies based on individual patient needs. Just as a desert traveler carefully chooses their route to minimize the risk of dehydration, healthcare professionals must carefully select medications and protective measures to balance the benefits and risks for their patients.

Dr.Camel's Conclusion

NSAIDs, like a double-edged sword, can provide pain relief but also pose risks to the stomach. This research, like a wise desert guide, helps us understand the protective effects of different medications. It underscores the importance of a personalized approach, considering individual patient needs and carefully weighing the potential benefits and risks of treatment options. Remember, just as a camel adapts to survive in harsh environments, we must carefully navigate the use of medications to ensure both pain relief and optimal gut health.

Date :
  1. Date Completed 1995-02-06
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

7818585

DOI: Digital Object Identifier

7818585

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Article Analysis
・Effects of diclofenac and misoprostol
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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