Paper Details

  1. Home
  2. Paper Details

Dissolution of pancreatic stones by oral trimethadione in patients with chronic calcific pancreatitis.

Author: KobayashiT, MurayamaH, NodaA, OkuyamaM, TakayamaT, TakeuchiK, YokotaT

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the efficacy of oral dissolution therapy using trimethadione in patients with chronic calcific pancreatitis. Pancreatic stones were dissolved in 70% of patients during a mean follow-up period of 32 months. Trimethadione also improved exocrine pancreatic function and controlled diabetes mellitus.
Paper Details　
Original Abstract of the Article :
The effect of oral dissolution therapy for pancreatic stones was evaluated in patients with chronic calcific pancreatitis. The anti-epileptic agent trimethadione was given orally to 30 outpatients at a dose of 0.9-1.5 g daily. On plain X-ray films and CT scans of the abdomen, pancreatic stones began...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1440-1746.1994.tb01278.x

データ提供：米国国立医学図書館（NLM）

Dissolving Pancreatic Stones: A Desert Oasis of Relief

The [treatment of chronic calcific pancreatitis] is a challenging area of medicine, often involving debilitating pain and digestive complications. This study investigates the use of [oral trimethadione] to dissolve pancreatic stones. Much like a desert oasis providing relief to weary travelers, this study explores a potential solution to a persistent medical problem.

A Novel Approach to Pancreatic Stones

The study's findings show that [oral trimethadione] can be effective in dissolving pancreatic stones in a significant proportion of patients. The study observes that [pancreatic stones began to be dissolved around 8 months of treatment] and [diminished in size and number or disappeared in 21 patients (70%)]. This is a remarkable finding, suggesting that trimethadione may offer a new avenue for treating this challenging condition.

Hope on the Horizon for Pancreatic Stones

The study offers a beacon of hope for patients with [chronic calcific pancreatitis]. The findings suggest that [trimethadione treatment] may offer a viable alternative to more invasive procedures. While the desert may seem endless, this research provides a glimmer of light, suggesting that relief may be possible through this novel treatment approach.

Dr.Camel's Conclusion

This study provides promising evidence that oral trimethadione can be effective in dissolving pancreatic stones. The findings offer hope for patients suffering from chronic calcific pancreatitis and suggest that trimethadione may be a valuable addition to the treatment arsenal for this challenging condition.

Date :
  1. Date Completed 1995-02-23
  2. Date Revised 2019-08-30
Further Info :

Pubmed ID

7827299

DOI: Digital Object Identifier

10.1111/j.1440-1746.1994.tb01278.x

Related Literature

Article Analysis
・Side Effects of trimethadione
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.