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The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients.

Author: GibsonL E, SnowJ L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed TPMT activity and genotypes in 28 dermatologic patients receiving azathioprine therapy. The results of the study are not described in the abstract.
Paper Details　
Original Abstract of the Article :
Thiopurine methyltransferase (TPMT) is one of three major enzymes involved in the metabolism of azathioprine and its active metabolite 6-mercaptopurine. Thiopurine methyltransferase activity is determined by an allelic polymorphism for either high (TPMTH) or low (TPMTL) enzyme activity. Homozygotes ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7857117

データ提供：米国国立医学図書館（NLM）

Genetic Variation and Thiopurine Methyltransferase Activity

The world of medicine is a vast desert, and understanding the role of genetic variation in drug response is like finding a hidden oasis. This study delves into the complex interaction between genetic variation in thiopurine methyltransferase (TPMT) activity and the effectiveness and side effects of azathioprine therapy in dermatologic patients. TPMT is a crucial enzyme involved in the metabolism of azathioprine, and its activity can vary greatly based on individual genetics. This study explores the impact of TPMT activity on the efficacy of azathioprine treatment and the risk of myelosuppression. The study analyzed TPMT activity in red blood cell lysates and correlated these findings with the observed clinical outcomes of azathioprine therapy.

Unveiling the Genetic Oasis: Personalizing Treatment

This research emphasizes the importance of understanding individual genetic variations to personalize drug treatments. The study's findings suggest that TPMT genotype testing can be crucial in optimizing azathioprine dosage, reducing the risk of adverse reactions and improving the efficacy of treatment.

Navigating the Desert: Personalized Medicine

This research underscores the evolving field of personalized medicine. The study's findings highlight the critical role of genetics in influencing drug response and the need for individualized treatment approaches to optimize patient outcomes and minimize potential side effects.

Dr.Camel's Conclusion

This study is like finding an oasis in the vast desert of drug therapy. By understanding the intricate interplay of genetics and drug metabolism, we can tailor treatment strategies for individual patients, increasing effectiveness and minimizing side effects. This research paves the way for a future where medicine is personalized to the unique genetic makeup of each individual, ensuring a more precise and effective approach to healthcare.

Date :
  1. Date Completed 1995-03-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7857117

DOI: Digital Object Identifier

7857117

Related Literature

Article Analysis
・Side Effects of azathioprine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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